Patient who underwent a total hysterectomy with or without adnexal surgery for benign uterine diseases with risk difficult operation for benign hysterectomy Difficult operation,Hysterectomy,Intraoperative blood loss ,Excessive blood loss,Tranexamic acid
Conditions
Interventions
Administration of tranexamic acid before incised skin 15 minutes,Administration of placebo before incised skin 15 minutes
Experimental Drug,Placebo Comparator No treatment
Sponsors
Khonkaen hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Women age older than 18 years, who underwent a total hysterectomy with or without adnexal surgery for benign uterine disease 2.Patient who understands Thai language 3.One or more theses risk difficult benign hysterectomy 3.1BMI 25 Kg/m2or more 3.2Diagnosis of endometriosis or tuboovarian abscess 3.3Uterine weight greater than equal to 250 or more than 12week size by Geometric equation of a prolate ellipsoid formula gm 0.5236volume or Bimanual examination 3.4Previous abdominal surgery
Exclusion criteria
Exclusion criteria: 1.Active cardiovascular disease 2.Severe hypertension 3.Renal disorder (CrCL < 30ml/min) 4.Hematologic coagulopathy disease 5.Pathological diagnosis with gynecologic malignancy including intraoperative finding suspected malignancy 6.Women received anticoagulant drugs 7.Women who hypersensitivity to Tranexamic acid 8.History of VTE 9.Prophylaxis enoxaparin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss Intraoperation Milliliter | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hemoglobin 24 hours post operation g/dL,Post operative hematocrit 24 hours post operation %,Operation times Total time of operation Min,Blood transfusion During admit Not statistical method,Side effect During admit Not statistically method,Blood loss equal to more 500 Total time of operation mililiter | — |
Countries
Thailand
Contacts
Public ContactJinjuta Jindaluang
Khonkaen hospital
Outcome results
None listed