Leucine enriched essential amino acid supplementation plus resistance training enhances appendicular skeletal muscle mass in older adults: An open label randomized controlled trial

Improvement of appendicular skeletal muscle mass after with leucine-enriched essential amino acid supplement combine with specific geriatric-focus exercise program: An open-label randomized control trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20240918001

Enrollment

Registered

2024-09-18

Start date

2024-09-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcopenia Sarcopenia, Dietary Supplements, resistance training

Interventions

A leucine-enriched essential amino acid supplement of 2 g per day is prescribed. The volunteers are instructed to take the supplement after the resistance training exercise.,A leucine-enriched essenti

Experimental Dietary Supplement,Experimental Dietary Supplement

Leucine-enriched essential amino with resistance training exercise,Leucine-enriched essential amino alone.

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: Elderly volunteers age 65 years or older.

Exclusion criteria

Exclusion criteria: 1. Previous stroke 2. Unable to stand 3. Dementia 4. CKD stage 4 or more 5. High falling risk 6. Cognitive impairment or disabled patients

Design outcomes

Primary

Measure	Time frame
Appendicular skeletal muscle mass index: ASMI 6 months Body impedance analysis	—

Secondary

Measure	Time frame
Gait speed 6 months m/s,Handgrip strength 6 months kg	—

Countries

Thailand

Contacts

Public ContactChantas Mahaisavariya

Mahidol university

c.mahaisavariya@gmail.com0899685892

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026