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Intermittent pneumatic compression-induced changes in stroke volume predicts fluid responsiveness in Traumatic Brain injury and post-operative neurosurgery.

Intermittent pneumatic compression-induced changes in stroke volume predicts fluid responsiveness in Traumatic Brain injury and post-operative neurosurgery.

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20240419002
Enrollment
25
Registered
2024-04-19
Start date
2020-04-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intermittent pneumatic compression (IPC) which augments significant increases of venous flow is suggested in neuro ICU patients when pharmacologic venous thromboembolism is contraindicated. Whether IPC induced changes in stroke volume (SV) predicts fluid responsiveness (FR) in patients with Traumatic Brain injury and post-operative neurosurgery is still unknown. Intermittent pneumatic compression, stroke volume, fluid responsiveness, Traumatic Brain injury, post-operative neurosurgery

Interventions

The patients were categorized into 2 groups which were fluid responder (increases in cardiac output (CO) more than 10 percentage from baseline CO following fluid bolus) group and fluid non-responder (
Pneumatic leg compression protocol,Fluid non-response group

Sponsors

Phramongkutklao hospital foundation
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: patients who were diagnosed Traumatic Brain injury and post-operative neurosurgery and admitted to surgical intensive care unit, Phramongkutklao Hospital Age more than 20-year-old and treatment continuously in Phramongkutklao hospital were included in this study.

Exclusion criteria

Exclusion criteria: Patients who refuse to treatment and to be subject, contraindication and complication for pneumatic leg compression, esophageal doppler and fluid challenge.

Design outcomes

Primary

MeasureTime frame
Hemodynamic variables in four time points 2 minutes increases in cardiac output (CO) more than 10 percentage from baseline CO following fluid bolus

Secondary

MeasureTime frame
Cut-off point of percentage of changes in CO 2 minutes after perform fluid responsiveness Cardiac output following IPC to predict fluid responsiveness

Countries

Thailand

Contacts

Public ContactPANU BOONTOTERM

Phramongkutklao College of Medicine and Hospital

sapiens_panu@hotmail.com66879128696

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026