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A randomized clinical study of encapsulated kale extract for pain reduction and anti-inflammatory effect after surgical removal of impacted mandibular third molar

A randomized clinical study of encapsulated kale extract for pain reduction and anti-inflammatory effect after surgical removal of impacted mandibular third molar

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20231028001
Enrollment
40
Registered
2023-10-28
Start date
2023-01-02
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain in patients after surgical removal of impacted mandibular third molar pain, mandibular third molar, pro-inflammatory cytokines, alpha-amylase, kale

Interventions

500 mg each, 4 times a day, oral,400 mg tablet each, 4 times a day, oral
kale,NSAID

Sponsors

Residency Training Program in Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 25 Years

Inclusion criteria

Inclusion criteria: Healthy based on the criteria of American Society of Anesthesiologists (ASA) Level I and II, Following surgical removal of impacted mandibular third molar (mesioangulation)

Exclusion criteria

Exclusion criteria: Allergic to ibuprofen, inflammation after surgical removal of impacted mandibular third molar, take analgesic drug 1 week prior to surgery, psychological disorders, no communication nor co-operation

Design outcomes

Primary

MeasureTime frame
pain four days after surgical removal of impacted mandibular third molar VAS meter,salivary alpha-amylase activity 4 days after surgical removal of impacted mandibular third molar colorimetry,salivary transforming growth factor beta four days after surgical removal of impacted mandibular third molar ELISA

Secondary

MeasureTime frame
salivary matrix metalloproteinase 9 4 days ELISA

Countries

Thailand

Contacts

Public ContactVuttinun Chatupos

Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200 Thailand

vuttinunch@yahoo.co.th6653944455

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026