intraoperative blood loss in pregnant woman undergoes caesarean section due to placenta previa Keyword: Tranexamic acid, preoperative, placenta previa, intraoperative blood loss, caesarean section
Conditions
Interventions
Group 1 patients received the drug labeled T1 that was 1 g tranexamic acid of concentration (250mg/5ml) 20 ml in 80 ml NSS intravenous drip in 5 min before the skin incision. , Group T2 patients recei
Placebo Comparator Drug,Placebo Comparator Drug
Sponsors
none
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. All pregnant woman with placenta previa diagnosed by transabdominal or transvaginal ultrasound(if not clearly by TAS) confirmed at GA 28 week by obstetricians 3. undergoing caesarean delivery for placenta previa include elective c/s at term (37+ week) or emergency c/s due to placenta previa 4. Repeat ultrasound confirm before caesarean section 5. Age > 18 year and already informed consent
Exclusion criteria
Exclusion criteria: 1. Allergic patient to transamine 2. Undergo caesarean section due to placenta previa before GA 28 week 3. follow up by ultrasound during antenatal care and diagnosis was changed 4. Patient with showed any sign of adherent placenta on ultrasound 5. Patient with active cardiac, hepatic, renal disease 6. patient with risk factor for VTE such as prior VTE, thrombophilia disease**, hematologic cancer, immobilize patient, first degree relative history of VTE, morbid obesity BMI>40 7.Underlying disease of Coagulopathy, thrombocytopenia or on anticoagulant 8. patient cannot make decision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraoperative blood loss intraoperative intraoperative blood loss measured by amount of blood in suction add with diffrent weight between soaked gauze and dry gauze | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of PPH 24 hour postpartum measured blood loss 24 hr postpartum more than 1000 ml | — |
Countries
Thailand
Contacts
Public Contactsupakorn chaiyakarn
chonburi hospital
Outcome results
None listed