patients with hypertension presenting albuminuria more than 30 mg/g and taking more than one antihypertensive class more than 3 months albuminuria, albumin creatinine ratio, evening, hypertension, morning
Conditions
Interventions
received pills in the morning 6 to 10 am,received pills in the evening 6 to 10 pm
Morning group,Evening group
Sponsors
Navamindradhiraj University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 18-80 year Hypertension for more than 1 year At least one antihypertensive agent for more than 3 months and at least one antihypertensive agent in Angiotensin-converting enzyme inhibitor (ACEI) and/or Angiotensin receptor blocker (ARB) Well controlled blood pressure (systolic blood pressure < 150 mmHg, Diastolic blood pressure < 90 mmHg) albuminuria > 30 mg/g Renal function (estimated glomerular filtration rate, eGFR > 15 ml/min/1.73 m2)
Exclusion criteria
Exclusion criteria: End stage kidney disease Poor control blood pressure Severe comorbid disease for example congestive heart failure, active cancer Pregnancy Inflammatory disease or active infection for example arthritis, pyelonephritis Study termination criteria Flare of comorbid disease or active infection (Cancer, acute coronary syndrome or any underlying disease that effect renal function) after included in study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine albumin creatinine ratio 3 months after intervention UACR | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect to serum creatinine 3 months after intervention serum creatinine ,Effects of blood pressure 3 months after intervention Systolic and diastolic blood pressure | — |
Countries
Thailand
Contacts
Public ContactThanphisit Trakarnvanich
Faculty of Medicine, Navamindradhiraj University
Outcome results
None listed