Effects of melatonin on salivary stress markers

The effects of melatonin supplement on salivary cortisol and amylase

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220310009

Enrollment

Registered

2022-03-10

Start date

2022-03-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy melatonin saliva cortisol amylase

Interventions

melatonin consumption 1 time,placebo

Active Comparator Drug,Placebo Comparator Drug

melatonin,placebo

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. age 18 years or older 2. no underlying conditions 3. not taking any medication or oral contraceptives 4. not allergic to melatonin or lactose 5. not pregnant or lactating 6. not having period during time to collect saliva

Exclusion criteria

Exclusion criteria: 1. use melatonin within 24h prior to experiment 2. drink alcohol within 12h 3. eat food within 1 h prior to saliva collection

Design outcomes

Primary

Measure	Time frame
cortisol before and after drug elisa	—

Secondary

Measure	Time frame
amylase before and after drug elisa	—

Countries

Thailand

Contacts

Public ContactNattinee Jantaratnotai

Mahidol University

nattinee.jan@mahidol.ac.th0864255095

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026