symptoms of irritable bowel syndrome IBS symptom irritable bowel syndrome melatonin
Conditions
Interventions
Melatonin SR (2 mg) 1 tab before bedtime,Placebo taking 1 tab before bedtime
Placebo Comparator Drug,No Intervention No treatment
Sponsors
Ratchadapiseksompotch Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients age 18 years or more 2. The patients who have symptoms of irritable bowel syndrome at least 3 months before registry 3. The symptoms of IBS disturb activity daily life 4. Have sleep disturbance (Pittsburgh sleep quality index at least 5) 5. give the inform consent
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation 2. History surgery of gastrointestinal tract 3. History of neurological disorder 4. History of organic disease of gastrointestinal tract, liver disease, diabetes 5. shift worker 6. Taking sleeping pill within 2 weeks before registry 7. poor compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Irritable bowel syndrome symptoms after end of the intervention IBS severity score system | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep quality after end of the intervention Pittsburgh sleep quality index , Epworth sleepiness scale, Actigraphy,quality of life after end of the intervention SF-36 (The short form health survey-36), HADS (Hospital Anxiety and Depression Scale),rectal sensation after end of the intervention Anorectal manometry and rectal sensory testing | — |
Countries
Thailand
Contacts
Public ContactNatsida Rathanaviriyachai
Faculty of medicine, Chulalongkorn university
Outcome results
None listed