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Comparison of efficacy of 5% calcium sodium phosphosilicate and 8% arginine and calcium carbonate in reducing dentin hypersensitivity following non-surgical periodontal therapy

Comparison of efficacy of 5% calcium sodium phosphosilicate and 8% arginine and calcium carbonate in reducing dentin hypersensitivity following non-surgical periodontal therapy

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180611003
Enrollment
Unknown
Registered
2018-06-11
Start date
2018-09-28
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin hypersensitivity Chronic periodontitis Dentin hypersensitivity Root sensitivity Desensitizing agent Calcium sodium phosphosilicate Arginine and calcium carbonate

Interventions

5% CSPS and 1&#44
450 ppm fluoride&#44
Desensitizing toothpaste,8% arginine and calcium carbonate and 1&#44
Desensitizing toothpaste,1&#44
Calcium sodium phosphosilicate ,Arginine,Control

Sponsors

Faculty of Dentistry, Chulalongkorn University
Lead Sponsor
Department of Periodontology&#44
Collaborator
Chulalongkorn University
Collaborator

Eligibility

Sex/Gender
All
Age
30 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion and exclusion criteria are modified from the guidelines for the design and conduct of clinical trials on dentine hypersensitivity (Holland et al. 1997) 1.Adults between 30-65 years of age 2.Individual diagnosed with chronic periodontitis 3.Compliant about at least 2 teeth with DH after receiving at least one visit of scaling and root planing and diagnosed by dentist with air blast (Schiff’s score 2-3) or tactile stimulation (VAS sensitivity score more than 4, moderate to severe DH) 4.Good general health

Exclusion criteria

Exclusion criteria: 1.Symptom of DH prior to periodontal treatment 2.Using agents to treat hypersensitivity in the past 3 months 3.Pharmacotherapeutic histories that may compromise the protocol including the chronic use of anti-inflammatory, analgesic and mind-altering drugs 4.Allergy to either 5% calcium sodium phosphosilicate or 8% arginine and calcium carbonate 5.DH from dental caries, defective restoration, fractured tooth 6.Extensively restored teeth and those with restorations extending into the test area 7.Orthodontic appliance treatment within previous 3 months 8.Crowded teeth 9.Abutment teeth for fixed or removable prostheses

Design outcomes

Primary

MeasureTime frame
Schiff Cold Air Sensitivity Scale baseline, immediately after in-office apply desensitizing toothpaste, 1, 2 , 4, and 8 weeks A blast of air from a dental syringe will be applied. The investigator will assess patient response.

Secondary

MeasureTime frame
VAS sensitivity score baseline, immediately after in-office apply desensitizing toothpaste, 1, 2 , 4, and 8 weeks The examiner will move the explorer in mesiodistal direction on the area of exposed dentin and ask t,Overall VAS sensitivity score in daily life baseline, 1, 2 , 4, and 8 weeks Patient reported outcome using a questionnaire interview

Countries

Thailand

Contacts

Public ContactChantrakorn Champaiboon

Department of Periodontology, Faculty of Dentistry, Chulalongkorn University

chchampa@yahoo.com662-218-8850

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026