Ondansetron for prophylaxis of spinal morphine induced nausea during early rooming in breastfeeding: a randomized placebo controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160216003

Enrollment

160

Registered

2016-02-16

Start date

2012-12-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

After cesarean delivery under spinal anesthesia with morphine&#44

Interventions

: In a randomized&#44

double&#45

blinded study&#44

158 healthy patients having cesarean delivery under spinal anesthesia with 0.2 mg of morphine were randomized to have either 4 mg of ondansetron (ondansetron group) or normal saline (control group) in

immediately after delivery. ,: In a randomized&#44

immediately after delivery.

Active Comparator Drug,Placebo Comparator No treatment

Ondansetron,normal saline

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 18-50 years of age, ASA physical status I-II, singleton, gestational age over 37 weeks and scheduled for elective cesarean section under successful spinal anesthesia.

Exclusion criteria

Exclusion criteria: Allergy to any study medication, cardiovascular and neurological disease, renal impairment or refusal of breastfeeding within 8 hours after delivery.

Design outcomes

Primary

Measure	Time frame
incidence of nausea 8 hour chi square	—

Secondary

Measure	Time frame
severity of nausea, incidences of nausea,vomiting, itching, 8 and 24 hours chi square and chi square for trend for Likert's scale	—

Contacts

Public ContactKetchada Uerpairojkit

Unaffilliated

ketchada_cc@hotmail.com66896644730

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026