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Ondansetron,normal saline

2 trials

Sponsors

Faculty of Medicine, Chulalongkorn University

Conditions

After cesarean delivery under spinal anesthesia with morphine&#44Hypotension and bradycardia are common complications following spinal anesthesia, particularly in elderly patients with increased cardiovascular vulnerability. Ondansetron, a 5HT3 receptor antagonist, has been suggested to attenuate these effects by inhibiting the Bezold Jarisch reflex, a key mechanism underlying spinal anesthesia induced hypotension. Ondansetron

Phase 4

Ondansetron for prophylaxis of spinal morphine induced nausea during early rooming in breastfeeding: a randomized placebo controlled trial
Active, not recruitingTCTR20160216003
Faculty of Medicine, Chulalongkorn UniversityAfter cesarean delivery under spinal anesthesia with morphine&#44
Start: 2012-12-01Target: 160Updated: 2026-04-27
Effect of prophylactic ondansetron on hemodynamic changes in elderly patients following spinal anesthesia: A Randomized Controlled Trial
Active, not recruitingTCTR20260416008
Hypotension and bradycardia are common complications following spinal anesthesia, particularly in elderly patients with increased cardiovascular vulnerability. Ondansetron, a 5HT3 receptor antagonist, has been suggested to attenuate these effects by inhibiting the Bezold Jarisch reflex, a key mechanism underlying spinal anesthesia induced hypotension. Ondansetron
Start: 2026-06-01Target: 156Updated: 2026-04-27