Obesity
Conditions
Interventions
20 normal-weight and 20 overweight or obese women will receive 3 meals rich in monounsaturated fatty acids (56% of the caloric value). The meals will be accompanied by 500mL of orange juice (test meal
Other
Sponsors
Universidade Federal de Viçosa
Universidade Federal de Viçosa
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers; female; non-smoker; aged 20-40 years; normal weight (BMI between 18.5-24.9 kg / m 2) or overweight / obesity class I (BMI 25.0 to 35.0 kg / m2); stable weight in the last three months (less than 5% of usual weight).
Exclusion criteria
Exclusion criteria: Pregnancy; lactiontion; or menopause; infections or inflammation in the experiment days; inflammatory, heart, liver, renal, gastrointestinal and respiratory diseases; hormonal treatment or prescribed drug that affect the digestion and absorption of nutrients; in use of hormones or drugs that affect energy, glucose or lipid metabolism; smoker; history of abuse of alcohol or drugs; unstable weight in the last three months (higher than 5% of usual weight); athlete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The consumption of orange juice may prevent the inflammatory response by reducing at least 5% the expression of pro-inflammatory genes, in blood mononuclear cells, and in plasma proinflammatory cytokines concentration, after the consumption of monounsaturated fatty acids (2, 3 or 5 h postprandial), compared to the negative control (water consumption) and control (consumption of fructose).;The inflammatory posprandial response (2, 3 or 5 h) to monounsaturated fatty acid intake will be increased among overweight women, at posprandial times, compared to normal-weight women.;The improvement in the inflammatory posprandial response (2, 3 or 5 h) to orange juice consumption will be lower in overweight women, compared to normal-weight women.;The metabolic response (serum glucose, insulin, triglycerides, uric acid, total cholesterol, HDL-c and LDL-c concentrations) to monounsaturated fatty acid intake will be different between normal-weight and obese women at postprandial time.;Satiety, measured by the visual analogue scale, will be lower in the group of overweight women compared to the normal-weight, independent of the meal.;The satiety will be greater in the meal consumed together with orange juice, followed by the meal with fructose, and finally by the meal consumed along with water. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected. | — |
Countries
Brazil
Contacts
Public ContactHelen Hermsdorff
Universidade Federal de Viçosa
Outcome results
None listed