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Effect of Probiotic and Sorghum Beverage on Metabolic Responses of Normal Weight and Overweight Individuals

Effect of Probiotic (Lactobacillus rhamnosus) and Symbiotic Beverage with Extruded and Germinated Sorghum ([Sorghum bicolor (L.) moench]) on Metabolic Responses of Adults

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-32v2gm5
Enrollment
Unknown
Registered
2023-04-05
Start date
2023-05-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight

Interventions

Double-blind study (volunteers and researchers will not know which drink will be ingested
drinks will receive codes assigned by people who are not responsible for the study), controlled, in a completely randomized design, lasting eight weeks. For this phase, 3 beverages will be used: bever

Sponsors

Universidade Federal de Viçosa
Lead Sponsor
Universidade Federal de Viçosa
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: fasting capillary blood glucose ranging from 70 to 99 mg/dL; regular breakfast intake; Body Mass Index (BMI) between 27 and 34.9 kg/m²; body fat percentage > 30% for females and > 20% for males; increased waist circumference; have a level of light physical activity; level of food restriction/disinhibition = 14

Exclusion criteria

Exclusion criteria: smokers; alcohol consumption greater than 2 doses/day (> 50g of ethanol/day); use of medications that affect blood glucose, energy metabolism or appetite; use of medications, herbs, or diets to reduce appetite and body weight; weight instability (gain or loss of more or less 3 kg in the 3 months prior to the beginning of the study); recent change in physical activity level; aversion, intolerance or allergy to food provided in the study; existence or history of recent digestive, liver, kidney, cardiovascular, thyroid or inflammatory diseases, diagnosis of cancer in the previous year; report of eating disorders; pregnant or lactating; use of laxatives or antibiotics in the three months prior to the beginning of the study; continuous use of anti-inflammatory drugs and/or corticosteroids; use of probiotics, prebiotics or synbiotics (> 2 times a week) in the month prior to the beginning of the study; menstrual irregularity three months prior to the start of the study

Design outcomes

Primary

MeasureTime frame
It is expected to find a reduction in biochemical and oxidative stress markers, assessed through blood tests, using assay kits, based on the verification of reduction in pre- and post-intervention measurements by statistical analysis.;It is expected to find a reduction in proteins related to adipogenesis, obesity and inflammation, evaluated through blood tests, using test kits, based on the observation of reduction in pre- and post-intervention measurements by statistical analysis.;It is expected to find a reduction in the subjective sensations of appetite, assessed by the application of a 10 cm Visual Analogue Scale (VAS), based on the observation of a reduction in pre- and post-intervention measurements by means of statistical analyses.;It is expected to find a reduction in anthropometric measurements and an improvement in body composition. Anthropometry will be evaluated by measuring weight, height, hip, waist and neck circumference and body composition by Dual Energy X-Ray Absorptiometry (DEXA). The expected reduction will come from the finding of reduction in pre- and post-intervention measurements by statistical analyses.

Secondary

MeasureTime frame
Secondary outcomes are not expected

Countries

Brazil

Contacts

Public ContactLucimar da Silva

Universidade Federal de Viçosa

lucimar.aguiar@ufv.br+553136125217

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 4, 2026