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Effect of creatine associated with a resistance training on muscle mass, strength and physical fitness in elderly with loss of muscle mass

Effect of creatine supplementation associated with a resistance training program on muscle mass, strength and physical performance in sarcopenic elderly

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2shfhj
Enrollment
Unknown
Registered
2016-09-08
Start date
2014-07-04
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sarcopenia, Health of the Elderly, Exercise, Insulin Resistance, Inflammation Mediators

Interventions

Experimental group: 14 subjects supplemented with 5 grams creatine monohydrate per day after lunch, when there is no resistance training, or 5 grams of creatine plus 100 grams of maltodextrin immediat
Dietary supplement
G11.427.590.530.698.277
D02.078.370.280
D26.660

Sponsors

Faculdade de Nutrição da Universidade Federal de Goiás
Lead Sponsor
Faculdade de Nutrição da Universidade Federal de Goiás
Collaborator

Eligibility

Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Between 60 and 80 years of age.

Exclusion criteria

Exclusion criteria: Vegetarian; Have taken any ergogenic aid in the last six months prior to study initiation; ingest any medication that is able to affect muscle growth or the ability to train intensely during the study, such as statins, muscle relaxants, anti-inflammatory; be involved in restricting food programs; be involved in physical training programs; have received contrast or performed radioactive procedure during the last year; is diagnosed with any kidney, liver and heart diseases.

Design outcomes

Primary

MeasureTime frame
Negative association between lean mass gain, assessed by Dual-energy X-ray absorptiometry, and the insulin resistance index, measured by HOMA-IR method (the homeostatic model assessment), and insulin concentrations, measured by Enzyme-Linked Immunosorbent Assay (ELISA), based on a correlation coefficient lower than -0.50.;Reduction in glucose concentrations assessed by enzymatic colorimetric method, based on the statement of a difference of at least 5% in between groups. ;Reduction in interleukin 6 concentrations assessed by by Enzyme-Linked Immunosorbent Assay (ELISA), based on the statement of a difference of at least 5% after intervention.—

Secondary

MeasureTime frame
Increase in interleukin 10 concentrations assessed by by Enzyme-Linked Immunosorbent Assay (ELISA), based on the statement of a difference of at least 5% after intervention. ;Reduction in adiponectin concentrations assessed by by Enzyme-Linked Immunosorbent Assay (ELISA), based on the statement of a difference of at least 5% after intervention. ;Reduction in leptin concentrations assessed by by Enzyme-Linked Immunosorbent Assay (ELISA), based on the statement of a difference of at least 5% after intervention.—

Countries

Brazil

Contacts

Public ContactJoão Mota

Faculdade de Nutrição da Universidade Federal de Goiás

jfemota@gmail.com+55(62)32096270

Outcome results

None listed

Source: REBEC (via WHO ICTRP)