Musculoskeletal Diseases
Conditions
Interventions
Control
Sponsors
Departement of anesthesiology Sahloul hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Age = 18 years • Scheduled for multilevel lumbar spinal fusion (= 2 levels) with decompression • ASA physical status I–II • Hemoglobin = 12 g/dL (women) or = 13 g/dL (men) at the anesthesia assessment • Platelet count between 150 × 10³/L and 500 × 10³/L • Prothrombin time = 70% and aPTT ratio < 1.2 • Written informed consent
Exclusion criteria
Exclusion criteria: • Congenital or acquired coagulopathy • Use of anticoagulants or ongoing antiplatelet therapy • History of thromboembolic disease • Renal impairment (creatinine > 120 µmol/L) • Hepatic dysfunction (ALT > 3× normal) • Coronary artery disease with stent • BMI > 40 kg/m² or weight > 100 kg • Pregnancy or breastfeeding • Hypersensitivity to fibrinogen or tranexamic acid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage decrease in hemoglobin concentration (%?Hb) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Perioperative blood loss (estimated and visible) ;• Red blood cell transfusion (yes/no and volume) ;• Surgeon-reported intraoperative bleeding ;• Adverse events up to 28 days | — |
Countries
Tunisia
Contacts
Public ContactMohamed Soussi
University of Sousse Faculty of Medicine of Sousse Sahloul hospital Department of Anesthesia and Reanimation 4011 Sousse Tunisia
Outcome results
None listed