Fibrinogen

DRUG11 trials

Conditions

BleedingBleeding in patients undergoing complex cardiac surgery involving Cardiopulmonary bypassBlood Coagulation DisorderBruisingCardiac Complication During ProcedureComplicationsCoronary Artery DiseaseHaemorrhage

Phase 1

Dilutional Coagulopathy in Patients Undergoing Elective Surgery

CompletedNCT00493272

Christian Fenger-EriksenBlood Coagulation Disorder

Start: 2007-06-30End: 2008-04-30Updated: 2015-12-02

Phase 2

Fibrinogen and Bleeding After Cardiac Surgery

CompletedNCT00968045

Sahlgrenska University HospitalBleeding, Complications, Coronary Artery Disease

Start: 2009-04-30End: 2015-05-31Updated: 2015-05-20

Pilot Randomized Trial of Fibrinogen in Trauma Haemorrhage

CompletedNCT02344069

Rigshospitalet, DenmarkHaemorrhage, Trauma

Start: 2015-02-28End: 2017-04-30Updated: 2017-04-11

Phase 3

The ZEro PLASma Trial (ZEPLAST): Avoidance of Fresh Frozen Plasma in Cardiac Surgery

CompletedNCT01471730

IRCCS Policlinico S. DonatoHeart Disease

Start: 2011-11-30End: 2014-12-31Updated: 2015-03-31

The Efficacy of the Administration of Fibrinogen in Liver Transplantation

NCT01539057

Hospital Universitari de BellvitgeIntraoperative Bleeding

Start: 2012-07-31End: 2015-01-31Target: 132Updated: 2014-12-04

Prospective Double Blinded Randomized Control Study of the Use of Fibrinogen in High-Risk Cardiac Surgery

CompletedNCT01623531

Nova Scotia Health AuthorityCardiac Complication During Procedure

Start: 2014-02-28End: 2019-06-30Updated: 2020-05-22

A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)

CompletedCTIS2022-501353-37-00

Astrazeneca AB, Astrazeneca ABand who have a major risk of bleeding., or edoxaban) who require urgent surgery or procedure, Reversal of anticoagulation effect in patients on a FXa inhibitor (apixaban +1

End: 2024-06-13Target: 467Updated: 2024-02-19

A multicenter, randomized, double-blind, placebo-controlled, parallel, phase 3 study to assess the efficacy and safety of fibrinogen concentrate (FGTW) in the management of bleeding in patients undergoing complex cardiac surgery (involving CPB)

RecruitingCTIS2024-512388-29-00

LFB-BiotechnologiesBleeding in patients undergoing complex cardiac surgery involving Cardiopulmonary bypass

Start: 2022-11-29Target: 104Updated: 2025-10-14

Phase 4

Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients

CompletedNCT04376762

University of VirginiaBleeding, Pediatric HD

Start: 2021-10-26End: 2023-05-01Updated: 2026-03-06

Unknown Phase

Study Evaluating Benefit of Using Fibrin Glue in Septorhinoplasty

TerminatedNCT00713596

Mayo ClinicBruising, Recovery Time

Start: 2008-07-31End: 2010-01-31Updated: 2016-04-18

Prospective comparison of plasma- or serum-based assays of D-dimer and fibrin degradation product for diagnosing periprosthetic joint infection

Active, not recruitingChiCTR2000038547

West China Hospital, Sichuan Universityhip and knee joint disease

Start: 2020-10-20Updated: 2021-03-15

Scientific Reports2024-08-165 citations

Factors associated with mechanical ventilation longer than 24 h after liver transplantation in patients at risk for bleeding.

2023-11-022 citations

Ability of plasma-based or serum-based assays of D-dimer and FDP for diagnosing periprosthetic joint infection: protocol for a prospective single-centre, parallel comparative study

BMJ Open2021-07-013 citations

Correlation between plasma fibrinogen and FIBTEM thromboelastometry during liver transplantation: a comprehensive assessment.

2017-10-088 citations

Pilot Randomized trial of Fibrinogen in Trauma Haemorrhage (PRooF-iTH): study protocol for a randomized controlled trial.

2016-07-1919 citations

Randomized, Double‐Blinded, Placebo‐Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery

Journal of the American Heart Association2015-06-02176 citations