N-acetylcysteine for root canal treatment of necrotic teeth with apical periodontitis.

Evaluation of N-acetylcysteine as an intracanal and adjunctive systemic medication in root canal treatment of necrotic mature teeth with apical periodontitis: a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202511513893768

Enrollment

Registered

2025-11-13

Start date

2025-10-30

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

UltraCal XS calcium hydroxide

N acetylcysteine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mature necrotic teeth. Radiographic evidence of periapical bone loss. Teeth that require primary endodontic treatment. Restorable teeth.

Exclusion criteria

Exclusion criteria: Immature teeth Teeth that had been previously accessed or endodontically treated. Teeth with periodontal pockets deeper than 4 mm. Patients with acute apical abscess. Patients with systemic diseases. Pregnant females. Patients who received antibiotic therapy within the past month. Patient on analgesics.

Design outcomes

Primary

Measure	Time frame
Postoperative pain intensity;Assessment of periapical healing	—

Secondary

Measure	Time frame
Change in the level of periapical tissues biomarkers	—

Countries

Egypt

Contacts

Public ContactMahmoud Aboelseoud

Assistant Professor

mahmoud.aboelseoud@alexu.edu.eg+0201222345986

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026