Cardiology
Conditions
Interventions
Traditional managment
Sponsors
Assiut university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Adults aged = 18 years. • Adult RHD patients with moderate to severe MR. • Patients with sinus rhythm
Exclusion criteria
Exclusion criteria: • Heart failure with reduced LVEF. • Secondary or functional MR or any other cause of primary MR. • Combined significant valve lesion. • Any concomitant degree of significant valvular stenosis. • Atrial fibrillation. • Known allergy or hypersensitivity to SGLT-2 inhibitors. • Women who are pregnant, lactating, or who plan to become pregnant while in the trial. • Non dialysis chronic kidney disease with eGFR <20 mL/min/1.73 m2 or those on dialysis. • Current use of SGLT2i • Occurrence of ant new attack of rheumatic activity during
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess effect of gliflozins on LA and LV strain parameters in rheumatic MR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess effect of gliflozin on EROA, RV, LVEF, LVESD, LVEDD, LVEDV, LVESV, TR, PASP and LAVI NYHA class, heart failure hospitalization, development of atrial fibrillation and the need to undergo surgical intervention | — |
Countries
Egypt
Contacts
Public ContactDoaa Fouad
Professor
Outcome results
None listed