Melatonin Versus Tizanidine with Cervical Plexus Block for Thyroidectomy

A Randomized Comparative Study of Effect of Preanesthetic Melatonin Versus Tizanidine Combined with Superficial Cervical Plexus Block on Anesthetic Outcome of Thyroidectomy Surgeries

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202503835746796

Enrollment

Registered

2025-03-04

Start date

2025-02-26

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Melatonin

Tizanidine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1-Either sex. 2- Age group 20 – 60 years old. 3- ASA physical status I-II. 4- Scheduled for thyroidectomy surgery.

Exclusion criteria

Exclusion criteria: 1- Age 60 years old. 2- ASA physical status >II. 3- Mental illness. 4- Drug abuse. 5- Patient refusal. 6- Concurrent treatment by any medication that prolongs QT interval. 7- Known hypersensitivity to any of the studied drugs. 8- Difficult intubation or complicated surgery.

Design outcomes

Primary

Measure	Time frame
Time to first request for rescue analgesia	—

Secondary

Measure	Time frame
Hemodynamic stress response to intubation;Intraoperative hemodynamics.;Isoflurane consumption;Time to awakening;Agitation score;Numeric rating score for pain at rest;Numeric rating score for pain at swallowing;Severity of postoperative nausea and vomiting;Total postoperative Ketorolac consumption;Total postoperative nalbuphine consumption;Intraoperative bradycardia;Occipital headache	—

Countries

Egypt

Contacts

Public ContactSalma Ahmed

Lecturer of Anesthesia Surgical Intensive Care and pain management Faculty of Medicine Mansoura University Egypt

salmaelsayed84@mans.edu.eg+201002990553

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026