Effect Of N-Acetylcysteine On Neonatal Outcomes Of Perinatal Asphyxia; A Multicentre, Double-Blind Randomised Control Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202409657658949

Enrollment

Registered

2024-09-03

Start date

2024-10-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paediatrics

Interventions

N acetylcysteine

Sterile water

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inborn late preterm and term babies in the participating hospitals

Exclusion criteria

Exclusion criteria: a. A neonate whose mother has chorioamnionitis (defined as maternal fever =38°C in the presence of rupture of membranes or 2 clinical findings: uterine tenderness, maternal white blood cell >15,000 cells/mm, foetal tachycardia >160 bpm, or malodorous amniotic fluid). b. A neonate whose prothrombin time is prolonged. c. A neonate whose mean BP is < 40 mmHg.

Design outcomes

Primary

Measure	Time frame
The duration to recovery based on daily monitoring with the Thompson Score is the primary outcome.	—

Secondary

Measure	Time frame
Neurodevelopmental outcome	—

Countries

Nigeria

Contacts

Public ContactVictor Ayeni

Lecturer and Consultant Neonatologist at Babcock University and Babcock University Teaching Hospital Ilishan Remo

tioluwa@hotmail.com+2348059324867

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026