Paediatrics
Conditions
Interventions
Sponsors
Babcock University
Babcock University Teaching Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a. Asphyxiated inborn late preterm and term babies in the participating hospitals. Diagnosis of PA defined satisfying at least two of the following parameters: (i) 5-minute APGAR score 10.0 mmol/L. b. Term neonates = 37 – 42 weeks EGA c. Birth weight = 2500g
Exclusion criteria
Exclusion criteria: a. A neonate whose mother has chorioamnionitis (defined as maternal fever =38°C in the presence of rupture of membranes or 2 clinical findings: uterine tenderness, maternal white blood cell >15,000 cells/mm, foetal tachycardia >160 bpm, or malodorous amniotic fluid). b. Evidence TORCH infections in the mother c. Use of antioxidants, high dose Vitamin C/E, or chronic corticosteroids by the mother in the peripartum period d. A neonate with family history of bleeding disorder e. A neonate whose cord blood demonstrates Glucose 6-phosphate dehydrogenase deficiency f. A neonate whose prothrombin time is prolonged. g. A neonate whose mean BP is < 40 mmHg. h. Presence of major congenital malformations, chromosomal abnormalities (e.g., Trisomy 21), or dysmorphic features suggestive of a genetic syndrome i. Meconium aspiration syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival and the duration to recovery based on daily monitoring with the Thompson Score is the primary outcome.;Survival and the duration to recovery based on daily monitoring with the Thompson Score is the primary outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroimaging findings;Neuroimaging findings | — |
Countries
Nigeria
Contacts
Public ContactVictor;Victor Ayeni;Ayeni
Senior Lecturer and Consultant Neonatologist at Babcock University and Babcock University Teaching Hospital Ilishan Remo;Senior Lecturer and Consultant Neonatologist at Babcock University and Babcock University Teaching Hospital Ilishan Remo
Outcome results
None listed