Cardiovascular disease
Conditions
Interventions
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age *18 and *75 years With or without significant coronary artery disease on CCTA as described earlier Written informed consent
Exclusion criteria
Exclusion criteria: Chronic infections Diabetes mellitus Medical history of any disease associated with immune deficiency (either congenital or acquired, including chemotherapy, chronic steroid use, organ transplant) Clinically significant infections within 3 months prior to study entry (defined as fever >38.5) Recent hospital admission or surgery with general anaesthesia (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of HSPC*s of patients with and without significant coronary artery disease on epigenetic and phenotypic characteristics, and relate this with phenotypic appearance of circulating monocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the pro-inflammatory monocytes and HSPC's phenotype with vascular wall inflammation, bone marrow and spleen activation by measuring FDG uptake in PET-CT scanning. | — |
Countries
The Netherlands
Outcome results
None listed