Adenomyosis of Uterus
Conditions
Keywords
adenomyosis, lower urinary tract symptoms, sexual dysfunction, gastrointestinal symptoms
Brief summary
To assess the efficacy of High-Intensity Focused Ultrasound on adenomyosis
Detailed description
Patients and methods: All outpatient patients with adenomyosis who will receive High-Intensity Focused Ultrasound therapy will be invited to participate in this study. The size and location of adenomyosis and the uterus should be assessed by ultrasonography. Besides, all enrolled female patients will be asked to complete visual analog scale of the severity of dysmenorrhea and the intensity of menstrual bleeding, overactive bladder symptom score, female bladder function (UDI-6 & IIQ-7), female sexual function index, and bowel incontinence assessment questionnaires. In addition, patients who underwent surgeries for myoma or adenomyosis will be requested to complete the above questionnaires and ultrasound examination at 3 months and 6 months after therapy.
Interventions
PROCEDUREHigh Intensity Focused Ultrasound
MRI guided High Intensity Focused Ultrasound
Sponsors
Far Eastern Memorial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. The patient must be at least 18 years old. 2. Adenomyosis: There must be several dark areas on at least one side of the uterine wall; the uterine wall must be thickened; in addition, the thickened uterine wall must have a nonhomogeneous structure; and clinically, there must be dysmenorrhea or menorrhagia.
Exclusion criteria
1. The patient currently has an acute lower urinary tract infection or intestinal inflammation. 2. The patient has previously undergone bladder or urethral surgery. 3. The patient has a history of urinary tract stones or tumors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dysmenorrhea | 6 months | The changes of VAS scores of dysmenorrhea |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall condition of dysmenorrhea | 6 months | The scores of Global response assessment in dysmenorreha after HIFU |
| Overall condition in menorrhagia | 6 months | Th scores of Global response assessment in menorrhagia after HIFU |
| Bowel incontinence | 6 months | The changes of the scores in the bowel incontience questtionnaires |
| Menorrhagia | 6 months | The change of VAS scores of menorrhagia |
| Overactive bladder symptoms | 6 months | The changes of Overactive Bladder Symptoms Scores |
| Female sexual function | 6 months | The changes of female sexual function index scores |
Countries
Taiwan
Outcome results
None listed