Radiotherapy Side Effect
Conditions
Brief summary
The study aims to provide a setup for collecting radiotherapy-related toxicity data, loco-regional control, and overall survival data for all Danish cancer patients undergoing reirradiation with high dose intention or with the aim of local tumour control; with the ultimate aim of providing safe reirradiation to a larger group of patients. To build a reirradiation cohort database for future research
Detailed description
Reirradiation of recurrent or new tumours has been associated with high rates of severe and even lethal toxicity in some previous reports \[Andratscske2023\]. This has led to many patients not being offered high dose reirradiation, even though they may potentially benefit from effective local treatment. Thus, it is extremely important to establish solid evidence of the risk of severe toxicity, to enable radiotherapy to be offered to these patients on an equal footing with patients treated for their first cancer. This prospective registration study will form the basis of a database enabling us to learn more about which patients are suitable for reirradiation, optimal constraints for organs at risk in reirradiation, overall survival, etc.
Interventions
RADIATIONReirradiation
reirradiation with all available modalities can be included
Sponsors
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* High dose reirradiation (reirradiation type I or II or repeat organ irradiation delivered with the aim of local control) Read Danish (for questionnaires + patient information) Life expectancy due to age and co-morbidity of ≥6 months. The general condition must be sufficient to tolerate persistent significant side effects Histological or imaging verified loco-regional recurrence, solitary oligo metastasis or new primary Age ≥18 years Signed informed consent, updated annually Expected follow up physical, by video, by phone or likely contact at a relevant oncological department Available dose plan(s) from primary (and prior) radiotherapy course(s) (with 3D reconstruction of previous plans, available port film, or drawings). Multiple re-treatments are allowed (new inclusion and baseline registration)
Exclusion criteria
* The primary and reirradiation treatments may not be quasi-simultaneous (i.e. the two treatments should be planned independently) Inability to attend full course of radiotherapy Purpose of radiotherapy is ONLY palliation of symptoms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Side effects | 5 years | CTCAE side effects |
Contacts
CONTACTHanna R Mortensen, PhD, MD
CONTACTCamilla JS Kronborg, PhD, MD
Outcome results
None listed