Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07325175

Enrollment

Registered

2026-01-08

Start date

2026-09-01

Completion date

2031-08-31

Last updated

2026-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Brain Stimulation, Dystonia, Motor Development, Pediatric

Brief summary

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

Interventions

DEVICEDBS

Subjects with DBS will complete protocol with and without active stimulation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

6 Years to 21 Years

Healthy volunteers

Yes

Inclusion criteria

* For dystonia subjects: * Dx of dystonia (with and without DBS) * willingness and ability to complete study protocols. * For Typically Developing Controls: * normal developmental milestones * absence of any neuropsychiatric disorder * no significant medical condition.

Exclusion criteria

* history of epilepsy * presence of implanted medical devices (except DBS in dystonia subjects) * lack of cognitive or physical ability to complete study protocol.

Design outcomes

Primary

Measure	Time frame
Longitudinal change in Motor Network Aperiodic Activity	-Baseline -Through study completion, an average of 2 years

Secondary

Measure	Time frame
Longitudinal change in Motor Network Periodic Activity	-Baseline -Through study completion, an average of 2 years
Longitudinal change in Motor Network EEG connectivity	-Baseline -Through study completion, an average of 2 years

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 12, 2026