Skin Transplantation, Wounds and Injuries, Antibiotic Prophylaxis Surgery
Conditions
Keywords
bangladesh, developing countries
Brief summary
The goal of this study is to see if putting antibiotic ointment on a skin graft when the surgery is being done helps prevent the skin graft from getting infected after the operation. The study is looking at all skin grafts done in a rural Bangladesh hospital. The main questions it aims to answer are: Does the antibiotic lower the number of infections that happen? Does the antibiotic make the overall outcome of the skin graft better? Do patients who get the antibiotic need fewer extra surgeries? Researchers will compare the outcomes from patients who had skin grafts before the hospital started applying antibiotic ointment to the outcomes of patients after the hospital began applying antibiotic ointment. Participants who have already had their skin graft treatment completed will have their medical records reviewed by researchers. The outcomes of their treatment will be written down.
Interventions
DRUGNeomycin
Topical neomycin was applied at the time of split-thickness skin graft surgery.
Sponsors
LAMB Project
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patient undergoing a split-thickness skin graft at the hospital where research is conducted
Exclusion criteria
* Missing or incomplete medical record
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative infection rate | Measured if present at any time during the patient's initial post-operative hospitalization, which averaged 20 days, from time of operation until time of discharge. | Whether patients had post-operative infection during their hospitalization, classified as yes or no as defined by any of the following being present: post-operative infection diagnosis written in the patient's medical record, change or increase in antibiotic therapy post-operatively, or the presence of pus documented at the skin graft site. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin graft take | Measured at the time of discharge from the patient's initial post-operative hospitalization, which averaged 20 days. | Percentage of skin graft that remained intact at the time of discharge, as estimated by the treating surgeon and documented in the patient's record. |
| Need for operative re-intervention | From the time of operation until the end of the study period (up to three years for the earliest skin graft patients). | Whether patient needed to return to the operating room for additional procedures (such as debridement or repeat skin grafting) for the same wound, classified as yes or no. |
| Length of stay | Measured at the time of discharge from the patient's initial post-operative hospitalization, which averaged 20 days. | Number of days spent in the hospital during the initial post-operative period. |
| Allergic reaction | Measured if present at any time during the patient's initial post-operative hospitalization, which averaged 20 days, from time of operation until time of discharge. | Whether patient had any allergic reaction to neomycin or any other substance documented - categorized as yes or no, based on the new presentation of rash or pruritis. |
Countries
Bangladesh
Outcome results
None listed