Knee Osteoarthritis (Knee OA)
Conditions
Keywords
Knee Osteoarthritis, Cross-linked Hyaluronic Acid, Recreational Athletes, Intra-articular Injection, WOMAC
Brief summary
Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of straight-chain (ST-HA) versus cross-linked (CL-HA) formulations remain limited. Therefore, the aim of this study was to compare the 6-month efficacy of a single dose of CL-HA versus two doses of ST-HA regarding pain, stiffness, and joint function in recreational athletes aged 50-70 with Kellgren-Lawrence grade 2-3 Knee OA refractory to pharmacological treatment.
Detailed description
This retrospective observational study included 88 recreational athletes (CL-HA: n=44, ST-HA: n=44). All participants received either a single dose of CL-HA or two doses of ST-HA administered 4 weeks apart. Patients were comparatively evaluated pre-treatment and at 1, 3, and 6 months post-treatment using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and VAS scores.
Interventions
DRUGStraight-bonded hyaluronic acid
Straight-bonded HA injection was applied in 2 doses, 4 weeks apart.
Cross-linked HA was applied as a single dose to the knee via the anterolateral approach.
Sponsors
Istanbul Medipol University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria: Recreational athletes aged 50-70 years; participants must not have received any injections or undergone physical therapy or rehabilitation in the last 3 months; and symptomatic cases of Kellgren-Lawrence stage 2-3 knee osteoarthritis and failure of pharmacological treatment.
Exclusion criteria
Inflammatory disease, active rheumatic disease, malignancy, bleeding diathesis, peripheral neuropathy, BMI \>30, grade 4 gonarthrosis, regular NSAID use, previous knee surgery, local infection at the procedure site, corticosteroid injection at the procedure site within the last 3 months, systemic corticosteroid use within the last 2 weeks, immunosuppressant use or immunodeficiency within the last 6 weeks, and any local or systemic osteoarthritis-related treatments (therapeutic exercises, physical therapy, other injections, NSAIDs, etc.) within the last 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patients were comparatively evaluated pre-treatment and at 1, 3, and 6 months post-treatment using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score. | Patients were comparatively evaluated pre-treatment and at 1, 3, and 6 months post-treatment | Minimal value is 0, while maximum value is 96. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patients were comparatively evaluated pre-treatment and at 1, 3, and 6 months post-treatment using the VAS score. | Patients were comparatively evaluated pre-treatment and at 1, 3, and 6 months post-treatment | Minimal value is 0, while maximum value is 10. |
Countries
Turkey (Türkiye)
Outcome results
None listed