Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients

A Randomized Clinical Trial; Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients Undergoing Laparoscopic Surgery at a Single Centre in Lebanon

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07201883

Enrollment

Registered

2025-10-01

Start date

2025-08-22

Completion date

2026-02-28

Last updated

2025-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting (PONV)

Keywords

PONV, Ondansetron, Postoperative Period, Vomiting, Laparoscopy, Antiemetics

Brief summary

The proposed randomized clinical trial aims to test and compare the efficacy of chewing gum vs. Intravenous antiemetic ondansetron as rescue treatment for post-operative nausea and vomiting (PONV) among Lebanese female patients undergoing laparoscopic surgery in the post-operative anesthesia care unit (PACU).

Detailed description

Post-operative nausea and vomiting remains a significant complication following general anesthesia, particularly when volatile anesthetics are used. Previous studies, including a multicenter randomized trial conducted in Australia, have explored alternative treatment modalities for PONV. Chewing gum, a non-pharmacological intervention, has shown promise as a potential alternative or adjunct to conventional antiemetics like ondansetron. This study focuses on the Lebanese female population, aged 18 and above, who have undergone laparoscopic surgery under volatile anesthetic-based general anesthesia. This demographic is chosen based on established risk factors for PONV and may offer unique insights into efficacy within this subgroup.

Interventions

DRUGOndansetron (Zofran)

4 mg IV push

OTHERchewing gum

Peppermint sugar free chewing gum

COMBINATION_PRODUCTOndansetron + Chewing gum

Ondansetron 4 mg IV push Peppermint sugar free chewing gum

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Females * Aged 18 and above, * Weight 40kg and above, * Who have undergone laparoscopic * Surgery under volatile anesthetic-based general anesthesia.

Exclusion criteria

* Have history of motion sickness, * Maintained anesthesia during surgery using Propofol-pump * Were given antiemetics within 8 hours pre-surgery * Allergy to ondansetron * Planned mechanical ventilation post-operation

Design outcomes

Primary

Measure	Time frame
Complete cessation of PONV with no recurrence and no rescue medication	2 hours

Secondary

Measure	Time frame
Patient satisfaction	post-operative period ( up to 3 hours)
Quantity of rescue treatment modalities used	immediately after PONV start until complete resolution of symptoms

Countries

Lebanon

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026