Heart Diseases, Cardiac Diseases, Vascular Diseases, Cardiovascular Diseases
Conditions
Keywords
Heart Disease, Cardiovascular Disease, Cardiology
Brief summary
The purpose of the Health eHeart BioBank is to collect and store specimen (e.g. blood, DNA, tissue) for future studies at the University of California, San Francisco (UCSF) that will help determine changes and identify molecular and genetic markers in the human body that might help increase our knowledge of heart disease and guide development of new diagnostic tools and treatments that may help rapidly detect heart disease and prevent and/or treat heart disease.
Interventions
PROCEDUREBlood Draw
Participants will be asked to contribute approximately 36 mL of blood using standard procedures and obtained at the time of a clinically ordered routine blood draw or a study ordered blood draw. Participants may be asked to contribute additional blood samples over the course of their participation in the study.
PROCEDURETissue Collection
If the participant is undergoing a clinically ordered procedure (e.g. heart surgery/biopsy/transplant), then they will be asked to contribute tissue to the study before any tissue is collected during the procedure. Most samples collected by the HeH BioBank will be tissue that would be normally discarded after the procedure.
PROCEDUREDNA Collection
Participants will be asked to contribute their DNA for Whole Genome Sequencing (WGS) to help identify genetic markers of heart disease. DNA will be obtained at the time of the blood draw or obtained through DNA collection kits administered to participants who are unable or unwilling to undergo a blood draw.
OTHERMedical Chart Review
Demographic, clinical, and pathologic information will be extracted from the participant's medical record.
Sponsors
University of California, San Francisco
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 years or older. And at least one of the following: * Established patient seen at UCSF and/or is a current participant in a clinical study that utilizes the HeH BioBank for biospecimen collection. * Family member of a patient with cardiovascular disease. * Patient with no cardiovascular disease.
Exclusion criteria
* Unwilling to consent to biospecimen collection through the HeH BioBank.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Establish and Maintain a Centralized Biorepository | Up to 10 years | Establish and maintain a centralized biorepository to collect and store a variety of biospecimen samples and clinical data. This would allow for the samples and clinical data to be used to test hypotheses regarding the molecular and genetic basis of diagnosis and treatment of cardiovascular diseases. |
Countries
United States
Outcome results
None listed