Tissue collection

PROCEDURE17 trials

Sponsors

Dartmouth-Hitchcock Medical Center, Dana-Farber Cancer Institute, University Health Network, Toronto, H. Lee Moffitt Cancer Center and Research Institute, Medical University of South Carolina

Conditions

Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Basal Cell Carcinoma of the Head and NeckBorderline Resectable Pancreatic Ductal AdenocarcinomaBreast CarcinomaCancerCardiac Diseases

Phase 1

GVAX Plus Checkpoint Blockade in Neuroblastoma

TerminatedNCT04239040

Dana-Farber Cancer InstituteNeuroblastoma, Pediatric Solid Tumor

Start: 2020-01-29End: 2024-02-29Updated: 2025-03-19

Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N

CompletedNCT04323202

Case Comprehensive Cancer CenterBasal Cell Carcinoma of the Head and Neck

Start: 2020-08-04End: 2025-06-25Updated: 2025-10-24

Phase 2

Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer

RecruitingNCT06635980

Mayo ClinicAnatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 +2

Start: 2025-05-14End: 2034-10-21Target: 120Updated: 2025-12-12

Unknown Phase

Phosphoproteomic Patterns as a Novel Biomarker for Aurora and Polo-like Kinase Inhibitors in Non-Small Cell Lung Cancer

CompletedNCT01510405

Dartmouth-Hitchcock Medical CenterNon-Small Cell Lung Cancer

Start: 2010-07-31End: 2020-04-30Updated: 2023-08-01

Detection of Tumor Associated Cell-free DNA in Peritoneal Fluid Obtained by Culdocentesis

TerminatedNCT02441140

Dana-Farber Cancer InstituteStage III Ovarian Cancer, Stage IV Ovarian Cancer

Start: 2015-05-31End: 2019-07-31Updated: 2020-05-04

Tissue Collection Protocol for Gastroesophageal Cancers

RecruitingNCT02495337

University Health Network, TorontoEsophageal Cancer

Start: 2015-05-31End: 2030-12-31Target: 100Updated: 2025-05-14

Determinants of Age-Related Treatment Effectiveness in Ovarian Cancer

CompletedNCT02973750

H. Lee Moffitt Cancer Center and Research InstituteFallopian Tube Cancer, Fallopian Tube Diseases, Ovarian Cancer +3

Start: 2016-10-20End: 2020-07-18Updated: 2023-01-26

Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH)

CompletedNCT03735745

Medical University of South CarolinaHead and Neck Cancer

Start: 2019-01-28End: 2022-07-15Updated: 2025-01-30

Memory Phenotype and PD-1 Inhibition Response in Oral Cancer

TerminatedNCT03862066

Medical University of South CarolinaSquamous Cell Carcinoma of the Head and Neck

Start: 2019-02-08End: 2021-11-22Updated: 2022-08-11

Microbiome and Rectal Cancer

Active, not recruitingNCT04223102

University of South FloridaLocally Advanced Malignant Neoplasm, Rectal Cancer

Start: 2020-02-18End: 2027-06-30Target: 40Updated: 2023-08-02

MicroRNA Markers in Head and Neck Cancers

Active, not recruitingNCT04305366

University of Colorado, DenverSquamous Cell Carcinoma of Head and Neck

Start: 2012-11-16End: 2027-02-01Updated: 2026-02-24

Patient Derived Preclinical Models

RecruitingNCT05324553

Mayo ClinicCancer

Start: 2022-04-06End: 2028-03-31Target: 50Updated: 2025-05-02

Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care

RecruitingNCT06331676

Hospices Civils de LyonEndometriosis

Start: 2024-06-21End: 2028-03-21Target: 90Updated: 2026-01-30

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

RecruitingNCT06349642

Mayo ClinicEarly Stage Lung Non-Small Cell Carcinoma, Early Stage Triple-Negative Breast Carcinoma, Metastatic Bladder Urothelial Carcinoma +24

Start: 2024-04-24End: 2027-05-01Target: 324Updated: 2026-03-12

Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan

RecruitingNCT06482957

Vanderbilt-Ingram Cancer CenterSarcoma

Start: 2022-04-01End: 2029-04-30Target: 2100Updated: 2025-09-19

Using Tumour DNA and Proteins to Better Understand How Pancreatic Cancer Responds to Treatment

RecruitingNCT06574620

British Columbia Cancer AgencyBorderline Resectable Pancreatic Ductal Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma, Pancreatic Ductal Adenocarcinoma +1

Start: 2025-11-28End: 2031-12-01Target: 200Updated: 2026-01-16

Health eHeart BioBank

Enrolling by invitationNCT06976502

University of California, San FranciscoCardiac Diseases, Cardiovascular Diseases, Heart Diseases +1

Start: 2025-04-01End: 2035-12-31Target: 500000Updated: 2025-06-06

Related Papers

Abstract PS4-01-08: Ex vivo cytokine profiling of live triple negative breast cancer patient specimens from core needle biopsies illustrates proof of concept to assess tumor response to immune checkpoint inhibition

Clinical Cancer Research2026-02-17

A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity

Journal of Translational Medicine2026-01-03

Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach.

2025-06-01

ELEPHAS-01, ELEPHAS-02 and ELEPHAS-04: Multi-institutional observational prospective clinical trials to assess the accuracy of an ex vivo live tumor fragment platform for predicting immunotherapy response.

Journal of Clinical Oncology2025-05-28

Phase 2 Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

Frontiers in Oncology2021-06-0811 citations