Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty

Evaluating the Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty: A Randomized Control Trial

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06902714

Enrollment

Registered

2025-03-30

Start date

2026-02-01

Completion date

2030-12-01

Last updated

2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shoulder Arthroplasty

Brief summary

The purpose of this clinical trial is to evaluate the short-term clinical outcomes of patients undergoing total shoulder arthroplasty who receive an extended postoperative course of oral tranexamic acid

Interventions

DRUGoral tranexamic acid

one group of subjects will receive oral tranexamic acid and the other will receive oral placebo

DRUGPlacebo

one group of randomized subjects will receive placebo and the other will receive oral tranexamic acid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 79 Years

Healthy volunteers

Inclusion criteria

* Skeletally mature patients (ages 18-79) undergoing primary total shoulder arthroplasty

Exclusion criteria

* Patients with Cancer, venous thromboembolism, stroke, heart disease, pregnant or nursing, allergic to TXA, current tobacco use, anticoagulants other than aspirin.

Design outcomes

Primary

Measure	Time frame	Description
VAS	2 weeks	visual analog scale

Countries

United States

Contacts

CONTACTWalter Smith

waltersmith@uabmc.edu205-930-8554

PRINCIPAL_INVESTIGATORWalter Smith, MD

University of Alabama at Birmingham

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026