Protein Metabolism
Conditions
Keywords
whole-body protein synthesis
Brief summary
Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).
Interventions
OTHERMILK
Drink containing amino acids in the composition of milk protein
OTHERWHEAT
Drink containing amino acids in the composition of wheat protein
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Protein beverages with milk- or wheat composition will look similar.
Intervention model description
Double-blind, randomized, parallel study design
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged between 65-85 years * BMI between 18.5-30 kg\*m\^-2 * Healthy, recreationally active (maximal one intensive exercise training per week) * No physical limitations (i.e., able to perform all activities associated with daily living independently)
Exclusion criteria
* Smoking * Diagnosed musculoskeletal disorders * Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories) * Chronic use of gastic acid-suppressing medication or anti-coagulants * Unstable weight over the last 3 months * Diagnosed GI tract disorders or diseases * Blood donation in the past 2 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in protein intake to maximize whole-body protein synthesis rates in older adults based on consumption of milk protein or wheat protein | From enrollment to the end of the study at 7 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in healthy older adults based on milk protein | From enrollment to the end of the study at 7 weeks |
| The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on milk protein | From enrollment to the end of the study at 7 weeks |
| The Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in older adults based on wheat protein | From enrollment to the end of the study at 7 weeks |
| The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on wheat protein | From enrollment to the end of the study at 7 weeks |
Countries
Netherlands
Contacts
Primary ContactLuc van Loon
Outcome results
None listed