Cardiometabolic Risk Factors, Inflammation, Microbiota
Conditions
Keywords
Blood lipid profile, Low grade inflammation
Brief summary
Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process. How nutritional composition of the diet affects the inflammatory response is however not well understood. The aim of this project is to study if intake of three different fat sources induce different effects on inflammation markers, blood lipids, blood glucose and the microbiota.
Interventions
OTHERRapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
OTHERButter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
OTHERCoconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.
Sponsors
Göteborg University
Chalmers University of Technology
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
Meals identical in apperance and taste will be prepared, and blinded.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-60 * Willing to eat the study diet
Exclusion criteria
* malabsorption-related condition * contraindications to consume a high fat diet * intolerance to any foods used in the study (e.g. cow's milk, egg, gluten) * established cardiovascular disease, diabetes or cancer * current use of medication known to affect lipid metabolism (e.g. statins) or inflammation (e.g. NSAID, glucocorticoids). * hemoglobin \<100 g/L * ongoing pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total cholesterol | Baseline and 1 week | — |
| hs-CRP | Baseline and 1 week | High sensitivity C-reactive Protein |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microbiota | Baseline and 1 week | Change in gut microbial composition and diversity (alpha- and beta). |
| Blood lipid propfile | Baseline and 1 week | Blood lipids and their subfractions, lipoproteins, apolipoproteins |
| Glucose | Continuous during 1 week | Glucose, measured by continuous blood glucose monitoring |
| Inflammation markers | Baseline and 1 week | Eg. GlycA, IL6, TNF-a |
Countries
Sweden
Outcome results
None listed