Acute Watery Diarrhea
Conditions
Brief summary
The current study was carried out to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii among the local pediatric population presenting with acute watery diarrhea.
Detailed description
The results and importance of effective treatment for acute watery diarrhea in pediatric patients vary throughout the world. Previously, very limited literature was available comparing the efficacy of Bacillus clausii and Saccharomyces boulardii in acute watery diarrhea, providing mixed results. The current study aims to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii.
Interventions
DRUGBacillus clausii
Children will be give Bacillus clausii for 5 days
Children will be give Saccharomyces boulardii for 5 days
DRUGZinc
Zinc will be given to all children for 5 days
DRUGORS
ORS will be given to all children for 5 days
Sponsors
RESnTEC, Institute of Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Months to 5 Years
Healthy volunteers
No
Inclusion criteria
* Patients of either gender * Aged 3 months to 5 years * With acute watery diarrhea last less fewer than 14 days * Presenting with mild to moderate dehydration
Exclusion criteria
* Patients with a history of blood or pus in their stools * History of recent antibiotic or probiotic treatment * Patients with immunodeficiency conditions, acute systemic illnesses, or chronic diarrhea * Patients with hypersensitivity to Bacillus clausii or Saccharomyces boulardii
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stool frequency | 5 days | Number of stools per day |
| Stool consistency | 5 days | Graded on a five-point scale as firm, soft, thick liquid, opaque watery, and watery |
Countries
Pakistan
Outcome results
None listed