Women, Sympathetic Nervous System, Aging, Blood Flow
Conditions
Brief summary
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Interventions
DRUGNorepinephrine
Infused intra-arterially in a dose-response fashion
DRUGIsoproterenol
Infused intra-arterially in a dose-response fashion
DRUGAcetylcholine
Infused intra-arterially in a dose-response fashion
DRUGNitroprusside
Infused intra-arterially in a dose-response fashion
DRUGEstrogen
Infused intra-arterially
Sponsors
American Heart Association (AHA)
University of Missouri-Columbia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Assigned female at birth (AFAB) * 18-70 years of age
Exclusion criteria
* Assigned male at birth (AMAB) * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Taking medications known to affect metabolic, autonomic, and/or respiratory function * Oral hormonal contraception in last 6 month * History of hormone replacement therapy * History of hyster- or oophor-ectomy * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Chronic disease * Blood pressure ≥140/90 mmHg * Communication barriers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnitude of forearm blood flow | Change from baseline during infusion |
Countries
United States
Contacts
Primary ContactJacqueline K Limberg
Outcome results
None listed