Lipoproteins, Inflammatory Response
Conditions
Keywords
Diet, Lipoproteins, T-Lymphocytes, Eggs, Aging
Brief summary
The goal of this intervention study is to determine whether consumption of different fractions of chicken eggs, including egg whites, egg yolks, and whole eggs, confer different changes in markers of HDL function and T cell profiles in younger vs. older men and women. The study will address the following objectives: * Objective 1: Determine if daily consumption of egg fractions differentially alter HDL profiles across age groups. * Objective 2: Determine if daily consumption of egg fractions differentially alter immune cell profiles across age groups. Participants will be asked to consume egg whites, egg yolks, and whole eggs on a daily basis for 4-weeks each, and avoid eating eggs for a total of 8 weeks at different points in the study. Participants will additionally be provided guidance on following a generally healthy diet, and will be asked to complete surveys about dietary intake and physical activity, as well as provide blood samples throughout the course of the study. Researchers will compare whether daily consumption of egg whites, egg yolks, and whole eggs differentially alter markers of HDL function and T cell profiles in younger vs. older adults.
Interventions
OTHERWhole eggs
3 large whole eggs per day for 4 weeks
OTHEREgg yolks
3 large egg equivalent of egg yolks per day for 4 weeks
OTHEREgg whites
3 large egg equivalent of egg whites per day for 4 weeks
Sponsors
American Egg Board
University of Connecticut
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-30 years old, or 50-75 years old (at time of screening) * Body mass index (BMI) \< 30 kg/m2 * Willing to consume whole eggs, egg whites, or egg yolks on a daily basis during study periods, and refrain from eating eggs during other study periods * Do not fit any
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum concentration of large HDL particles between diet periods | 4 weeks | Measurement of serum large HDL particles (nmol/L) at the egg-free run-in period and the end of each intervention arm. |
Countries
United States
Outcome results
None listed