Skip to content

Bone and Inflammatory Outcomes - Nutrition and Exercise Trials

Dairy Supplementation and the Post-Exercise Bone and Inflammatory Response

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06041087
Acronym
BIONEX
Enrollment
20
Registered
2023-09-18
Start date
2023-11-01
Completion date
2025-09-01
Last updated
2026-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Bone, Inflammation

Keywords

Bone health, Females, Dairy, Exercise, Inflammation

Brief summary

This study investigates whether dairy products will positively impact loading exercise-induced bone turnover and bone cell activity and/or the post-exercise inflammatory response in healthy young adults compared to a carbohydrate drink and/or water.

Detailed description

Introduction: Two million individuals at a cost of around 4.6 billion dollars a year in Canada suffer from osteoporosis. It is important to investigate strategies that can reduce bone loss and/or increase bone mass. Similarly, inflammation is associated with many different disease states, and investigating strategies to reduce systemic inflammation is prudent. Nutrition and exercise may be inexpensive and accessible strategies to improve bone health and inflammation and should be explored in different contexts and implemented. Our proposed research combines both nutrition and exercise along with the assessment of bone turnover and inflammatory markers in healthy young adults. Design: Randomized controlled crossover trial Participants: Healthy, university aged males and females. Methods: During the study participants will complete 4 different acute exercise and nutritional supplement trials, in random order. The four trials are: 1) exercise+carbohydrate (CHO), 2) exercise+milk (Milk), 3) exercise+Greek yogurt (GY), and 4) exercise+water (W). The whole study will take a maximum of 16 weeks and each supplement trial will be separated by 2-4 weeks. Outcomes: several markers of bone turnover and bone cell activity as well as markers of inflammation will be measured in the blood, before exercise and at different times post-exercise and post supplement consumption.

Interventions

A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.

50g consumed immediately after exercise and 1h after exercise.

DIETARY_SUPPLEMENTSkim Milk

500ml consumed immediately after exercise and 1h after exercise.

DIETARY_SUPPLEMENTGreek yogurt

200g consumed immediately after exercise and 1h after exercise.

DIETARY_SUPPLEMENTWater

500ml consumed immediately after exercise and 1h after exercise.

Sponsors

York University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* Between the ages of 18-30 years * Normal BMI (18.5-24.9) kg/m\^2 * Low to moderately physically active (0-2 times/week) * No allergy to dairy protein or lactose intolerance * On no medication related to a chronic condition * On birth control or naturally cycling with a regular menstrual cycle)

Exclusion criteria

* Regular smoker (cigarettes, e-cigarettes (e.g., vapes) or cannabis) * Any chronic condition, inflammatory, or auto-immune condition

Design outcomes

Primary

MeasureTime frameDescription
Acute Bone Turnover/Cell ActivityPre-exerciseOPG measured in serum/plasma
Systemic Inflammation - Serum/Plasma CytokinesPre-exerciseTNF-alpha measured in serum/plasma.
Systemic inflammation - Immune CellsPre-exerciseLeukocytes measured via flow cytometry

Secondary

MeasureTime frameDescription
Muscle sorenessPre-exerciseMuscle soreness rated on a 0-5 scale.
Performance - Jump HeightPre-exerciseVertical jump height measured using a counter movement jump technique.

Countries

Canada

Contacts

PRINCIPAL_INVESTIGATORAndrea R Josse, PhD

York University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026