Healthy
Conditions
Brief summary
A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.
Interventions
Inhaled hyperpolarized 129Xe used as a signal agent for MRI of the lungs.
Sponsors
University of Kansas Medical Center
Johns Hopkins University
University of Iowa
Duke University
University of Illinois at Chicago
Baylor College of Medicine
Temple University
University of Pennsylvania
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
25 Years to 35 Years
Inclusion criteria
* Is enrolled in the American Lung Association Lung Health Cohort Study. * Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.
Exclusion criteria
* Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, \> 140 cm shoulder circumference, dependent on weight distribution). * Is pregnant or breastfeeding * Oxygen saturation (SpO2) \<88% on room air or with supplemental oxygen.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Xe-MRI Apparent Diffusion Coefficient | At baseline imaging timepoint | Correlation of Xe-MRI with FEV1/FVC and other measures of lung function |
Countries
United States
Contacts
CONTACTCristal Monge
Outcome results
None listed