Hyperpolarized Xe129

DRUG10 trials

Sponsors

Mario Castro, MD, MPH, University of Kansas Medical Center, Bastiaan Driehuys, Children's Hospital Medical Center, Cincinnati, University of Virginia

Conditions

Acute Pulmonary EmbolismAnemiaAsthmaCOPDChronic Thromboembolic Pulmonary HypertensionCovid19Cystic FibrosisDyspnea

Early Phase 1

Regional Monitoring of CF Lung Disease

RecruitingNCT06339593

Children's Hospital Medical Center, CincinnatiCystic Fibrosis

Start: 2024-01-05End: 2028-01-31Target: 60Updated: 2026-01-14

Hyperpolarized Xenon-129 MRI in Idiopathic Pulmonary Fibrosis

RecruitingNCT06853145

University of VirginiaIdiopathic Pulmonary Fibrosis

Start: 2025-05-01End: 2027-12-31Target: 6Updated: 2025-07-09

Phase 1

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

RecruitingNCT04624490

Mario Castro, MD, MPHAsthma, COPD, Cystic Fibrosis +4

Start: 2020-11-02End: 2028-10-26Target: 260Updated: 2026-05-06

Hyperpolarized 129Xe MRI of Survivors of COVID-19

CompletedNCT04659707

University of Kansas Medical CenterCovid19

Start: 2021-02-22End: 2025-05-01Updated: 2026-05-01

Phase 2

129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study

WithdrawnNCT04677426

University of Kansas Medical CenterHypersensitivity Pneumonitis, Idiopathic Pulmonary Fibrosis

Start: 2022-05-01End: 2022-08-01Updated: 2022-09-10

129Xe MRI Cardiopulmonary

RecruitingNCT06038630

Bastiaan DriehuysAcute Pulmonary Embolism, Anemia, Chronic Thromboembolic Pulmonary Hypertension +3

Start: 2024-01-12End: 2028-06-30Target: 125Updated: 2026-02-04

Xenon MRI in Stable Pulmonary Hypertension (Jupiter AUGEAN)

WithdrawnNCT06122922

Bastiaan DriehuysPulmonary Artery Hypertension

Start: 2024-03-15End: 2025-12-31Updated: 2024-01-23

Unknown Phase

MRI for Screening and Monitoring Scleroderma ILD

CompletedNCT05204355

University of Kansas Medical CenterScleroderma

Start: 2022-05-01End: 2025-10-31Updated: 2026-05-01

Developing Hyperpolarized 129Xe MRI Biomarkers for Evaluation of Pulmonary Arterial Hypertension

CompletedNCT05339386

University of Kansas Medical CenterPulmonary Arterial Hypertension

Start: 2022-08-29End: 2025-07-31Updated: 2026-05-01

Hyperpolarized 129Xe MRI Lung Health Cohort

RecruitingNCT05766384

University of Kansas Medical CenterHealthy

Start: 2023-11-30End: 2027-03-31Target: 260Updated: 2026-05-01