Exercise, Ketosis
Conditions
Keywords
Efficiency
Brief summary
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency. Participants will perform three trials in a randomized order. Each trial will involve an incremental exercise protocol on a stationary cycle ergometer to volitional fatigue. Participants will ingest either a high or low dose of a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise efficiency.
Detailed description
This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency. Trained participants with cycling experience will be recruited. Participants will perform three trials in a randomized order. Each trial will involve a 3-minute warm-up followed by an incremental ramp test. The ramp will initially consist of three, 5-minute stages performed at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity. This will be followed by a further incremental ramp test to volitional fatigue. Participants will ingest either a high or low dose of a ketone supplement or a taste-matched placebo drink prior to exercise using a randomized, double-blind crossover design. Diet prior to exercise will be standardized between trials for a given participant. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise efficiency.
Interventions
DIETARY_SUPPLEMENTKetone monoester
A commercial liquid ketone monoester supplement.
OTHERPlacebo
A liquid placebo that is taste-matched to the ketone monoester supplement.
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Be habitually consuming ≥50 g/d of carbohydrate (i.e., not following a ketogenic diet). * Be engaged in endurance-type exercise \>3h/wk. * Have an estimated VO2peak of ≥90% for age and sex as estimated by an online calculator found at www.worldfitnesslevel.org.
Exclusion criteria
* Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering Yes to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise efficiency | Continuous measurement made over each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity | Power output expressed relative to pulmonary oxygen uptake to determine cycling economy in watt per litre of oxygen per minute |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | Continuous measurement made over each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity | Mean heart rate |
| Rating of perceived exertion | Measurement made at the end of each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity | Rating of perceived exertion measured using a 6-20 scale |
| Ketone body content in venous blood | Measurement made immediately prior to exercise | Mixed venous blood content of the ketone body beta-hydroxybutyrate |
Countries
Canada
Outcome results
None listed