Lipemia
Conditions
Keywords
Postprandial lipemia
Brief summary
The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA) have different impacts on postprandial blood lipid levels and appetite via a visual analog scale (VAS).
Detailed description
Postprandial lipemia has been recognized as a cardiovascular disease risk factor. The rate of postprandial triglyceride production and clearance in the blood, as well as the appetite, are influenced by the quality of the food consumed, such as the length of saturated fatty acids. The study will include 24 healthy adults ranging in age from 18 to 40 years old, of both sexes and it will be conducted at the University of Jordan. The study will involve two experimental test days, each separated by at least a week of washout interval, and each test day will last for 6 hours. All subjects will be randomly assigned to one of the experimental meals using computer-generated tables. Blood serum samples (2 mL) will be taken after an overnight fast and 2, 4, and 6 hours after eating the meals, and blood lipid profiles \[total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)\] will be examined in a private lab. After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated.
Interventions
DIETARY_SUPPLEMENTCoconut oil
Coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.
DIETARY_SUPPLEMENTPalm oil
Palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.
Sponsors
University of Jordan
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
randomized crossover single-blinded intervention study
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18-50 years * Males and females * Apparently healthy * Fasting triglyceride (TG) \< 2.5 mmol/L or 222 mg/dl at the time of screening. * Body mass index (BMI) in normal range (18.5-24.9). * Stable weight for at least 3 months
Exclusion criteria
* Consumption of lipid-lowering drugs or any medication that might affect appetite. * Consumption of any supplement that may affect lipid metabolism or appetite on a regular basis for the past month. * Regular consumption of two or more fish meals a week over the previous month. * A history of diabetes, gastrointestinal , liver disease, congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft or established atherosclerotic disease. * Current smokers * Pregnant , breastfeeding, postmenopausal or suffer from polycystic ovary syndrome (PCOS) * Athlete * Being on a diet or lifestyle changes for the past month.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anthropometric measurements ( Height) | baseline, pre-intervention, 1 day for each participant /during 3 months | Standing height, without footwear, will be taken using stadiometer to the nearest 5mm |
| Anthropometric measurements (Weight) | baseline, pre-intervention, 1 day for each participant /during 3 months | Bioelectrical impedance will be used to determine body weight |
| Anthropometric measurements (waist circumference) | baseline, pre-intervention, 1 day for each participant /during 3 months | Waist circumference (WC) will be measured at the midway between the lowest ribs and the iliac crest using a standard tape to the nearest 1 cm |
| Anthropometric measurements (percentage body fat) | baseline, pre-intervention,1 day for each participant /during 3 months | Bioelectrical impedance will be used to determine body composition |
| Biochemical measurements (Total cholesterol (TC)) | After the intervention / up to 3 months from collecting the samples | Up to 6 hours |
| Biochemical measurements (Low density lipoprotein cholesterol (LDL)) | Up to 6 hours | Low-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals |
| Biochemical measurements ( High density lipoprotein cholesterol (HDL)) | Up to 6 hours | High-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals |
| Biochemical measurements (Triglyceride (TG)) | Up to 6 hours | Triglyceride test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals |
| Dietary intake (3-days food record) | one day | Participants will be asked to fill out a food record to track changes in their (intake) appetite |
Countries
Jordan
Outcome results
None listed