Vitamin K2 and Muscle Weakness in Type 2 Diabetes

Effects Vitamin K2 on Muscle Mass and Function in People With Muscle Weakness and Type 2 Diabetes

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05375630

Acronym

SARK2

Enrollment

150

Registered

2022-05-16

Start date

2022-03-21

Completion date

2024-10-31

Last updated

2023-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabete Type 2

Brief summary

The aim of the current study is to determine the effects of vitamin K2 supplementation on muscle size and function in adults with muscle weakness and type 2 diabetes.

Interventions

DIETARY_SUPPLEMENTPlacebo

Placebo

DIETARY_SUPPLEMENTVitamin K2

Vitamin K2

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Masking description

Double blind

Intervention model description

Parallel Group Randomised Controlled Trial

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Physician confirmed type 2 diabetes. * Age \>/= 40 years * No changes in anti-diabetic medication in the last 3 months. * Muscle weakness (grip strength \<27kg and females \<16kg)

Exclusion criteria

* BMI of 45 or higher * BP of 160/100mmHg or higher * Cancer or cancer that has been in remission \<5 years * Any medical condition that prevents participants from exercising safely * On anticoagulant therapy * Currently consuming vitamin K2 supplements * Current smoker

Design outcomes

Primary

Measure	Time frame	Description
Grip Strength	Baseline to one year	Change in Grip Strength

Secondary

Measure	Time frame	Description
SPPB	Baseline to one year	Change in Short Performance Physical Battery Test
HbA1c	Baseline to one year	Change in glycated haemoglobin
Blood Pressure	Baseline to one year	Change in blood pressure
Body Mass	Baseline to one year	Change in body mass
BMD	Baseline to one year	Change in bone mineral density
Body Fat	Baseline to one year	Change in body fat
BMC	Baseline to one year	Change in bone mineral content
Vitamin K status	Baseline to one year	Change in vitamin K status
Lean Mass	Baseline to one year	Change in lean mass

Countries

Kuwait

Contacts

Primary ContactStuart Gray

stuart.gray@glasgow.ac.uk01413302569

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026