Relevance of Sensitization to Fenugreek in Children

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05340920

Enrollment

Registered

2022-04-22

Start date

2022-04-30

Completion date

2022-06-30

Last updated

2022-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergy to Fenugreek

Keywords

allergy, children, legumes, sensitization, diagnostic

Brief summary

The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. The overall goal of this study is to improve knowledge about fenugreek allergy. The principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. The secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific IgE and to compare the molecular profile of specific IgE to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy

Interventions

DIAGNOSTIC_TESTOral Food Challenge

diagnostic values of skin prick test and specific IgE for allergy confirmed by oral food challenge (routine, not an intervention)

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Children for whom an oral food challenge to fenugreek has been performed between the 1st January 2017 and the 15th April 2022 and for whom skin prick test and/or specific IgE to fenugreek are avalaible

Exclusion criteria

* patient over 18 years old * undeterminate oral food challenge

Design outcomes

Primary

Measure	Time frame	Description
Oral food challenge to fenugreek	2017-2022	Astier's score 0 to 4 (0=negative, 1 and 2=mild to moderate reaction, 3 and 4 = severe reaction)
skin prick-test to fenugreek	2017-2022	skin prick test positive if wheal size superior to 3mm
specific IgE to fenugreek	2017-2022	specific IgE positive if value superior to 0.35kU/L

Secondary

Measure	Time frame	Description
severity of allergy	2017-2022	reactogenic dose (from 1 to 1000mg of fenugreek)
molecular profile for peanut allergy	2017-2022	IgE values for rAra h1, h2, h3, h6, h8, h9

Countries

France

Contacts

Primary ContactAmandine Divaret-Chauveau, MD

a.chauveau@chru-nancy.fr+33 630094606

Backup ContactTimé Muller, MD

t.muller@chru-nancy.fr+33 630336839

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026