Exercise, Ketosis
Conditions
Keywords
Performance
Brief summary
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Participants will perform two trials in a randomized order. Each trial will involve a 20-minute bout of cycling on a stationary ergometer. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.
Detailed description
This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Trained participants with competitive cycling experience will be recruited. Exercise will involve a 20-minute bout of cycling on a stationary ergometer with the goal of producing the highest power output possible. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise using a randomized, double-blind crossover design. Diet prior to exercise will be standardized between trials for a given participant. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.
Interventions
OTHERPlacebo
A liquid placebo that is volume- and taste-matched to the ketone monoester supplement
DIETARY_SUPPLEMENTKetone monoester
A commercial liquid supplement ingested in a dose intended to provide \ 0.35 g of ketone monoester per kg body mass of the participant
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Habitually ingesting \>50 g of dietary carbohydrate daily i.e. not following a ketogenic diet. * Regularly performing cycling exercise at least 3 days per week and for a total of ≥5 hours per week. * Having an estimated peak oxygen uptake of ≥55 ml/kg/min for males and ≥48 ml/kg/min for females based on the online fitness calculator available at: www.worldfitnesslevel.org. * Having competitive cycling experience.
Exclusion criteria
\- Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering Yes to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Power output | 20-minute measurement during exercise | Mean power output produced while cycling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | 20-minute measurement during exercise | Mean heart rate while cycling |
| Perceived exertion | Single measurement immediately after exercise | Rating of perceived exertion while cycling |
| Blood ketone | Single measurement immediately prior to exercise | Blood ketone before exercise |
| Blood glucose | 20-minute measurement during exercise | Mean blood glucose while cycling |
Countries
Canada
Outcome results
None listed