Choroidal Neovascular Membrane, Diabetic Macular Edema, Neovascular Age-related Macular Edema, Non-proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy, Retinal Vein Occlusion
Conditions
Brief summary
Anti-vascular endothelial growth factor therapy is the major intervention for treating ischemic retina diseases. According to FDA and China Food and Drug Administration, Ranibizumab, Aflibercept, and Conbercept are major types of anti-vascular endothelial growth factor therapy drugs. In the current study, the primary aim is to observe the visual acuity, anatomy effect of anti-vascular endothelial growth factor therapy in the real-world setting.
Detailed description
Anti-vascular endothelial growth factor therapy is the major intervention for treating ischemic retina diseases, including neovascular age-related macular edema, diabetic macula edema/non-proliferative diabetic retinopathy / proliferative diabetic retinopathy, retinal vein occlusions related macular edema, and choroidal neovascularization secondary to multiple retinal diseases. According to FDA and China Food and Drug Administration, Ranibizumab, Aflibercept, and Conbercept are major types of anti-VEGF drugs. In the current study, the primary aim is to aim to observe the visual acuity, anatomy effect of anti-vascular endothelial growth factor therapy in the real-world setting.
Interventions
Ranibizumab 0.5mg/0.05ml intravitreal injection
Aflibercept 2.0mg/0.05ml intravitreal injection
Conbercept 0.5mg/0.05ml intravitreal injection
Sponsors
Study design
Eligibility
Inclusion criteria
* Patients with neovascular age-related macular edema (nAMD), diabetic macula edema (DME)/non-proliferative diabetic retinopathy (NPDR)/ proliferative diabetic retinopathy (PDR), retinal vein occlusions related macular edema, and choroidal neovascular (CNV) secondary to multiple retinal diseases. * Undergo intravitreal anti-VEGF therapy
Exclusion criteria
* unable to receive OCT examination * Severe corneal opacity, cataract that affect OCT examination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual acuity | 1 year | LogMAR visual acuity |
| Central subfield thickness | 1 year | he central subfield is defined as the circular area 1 mm in diameter centered around the center point of the fovea |
Countries
China