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Anti-VEGF in Real-world

Observation of Anti-vascular Endothelial Growth Factor Therapy in Exudative Age-related Macular Degeneration, Proliferative Diabetic Retinopathy, Macular Edema, and Choroidal Neovascularization.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05222633
Enrollment
1000
Registered
2022-02-03
Start date
2022-01-01
Completion date
2023-05-01
Last updated
2022-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Choroidal Neovascular Membrane, Diabetic Macular Edema, Neovascular Age-related Macular Edema, Non-proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy, Retinal Vein Occlusion

Brief summary

Anti-vascular endothelial growth factor therapy is the major intervention for treating ischemic retina diseases. According to FDA and China Food and Drug Administration, Ranibizumab, Aflibercept, and Conbercept are major types of anti-vascular endothelial growth factor therapy drugs. In the current study, the primary aim is to observe the visual acuity, anatomy effect of anti-vascular endothelial growth factor therapy in the real-world setting.

Detailed description

Anti-vascular endothelial growth factor therapy is the major intervention for treating ischemic retina diseases, including neovascular age-related macular edema, diabetic macula edema/non-proliferative diabetic retinopathy / proliferative diabetic retinopathy, retinal vein occlusions related macular edema, and choroidal neovascularization secondary to multiple retinal diseases. According to FDA and China Food and Drug Administration, Ranibizumab, Aflibercept, and Conbercept are major types of anti-VEGF drugs. In the current study, the primary aim is to aim to observe the visual acuity, anatomy effect of anti-vascular endothelial growth factor therapy in the real-world setting.

Interventions

DRUGRanibizumab

Ranibizumab 0.5mg/0.05ml intravitreal injection

DRUGAflibercept

Aflibercept 2.0mg/0.05ml intravitreal injection

Conbercept 0.5mg/0.05ml intravitreal injection

Sponsors

Wenbin Wei
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* Patients with neovascular age-related macular edema (nAMD), diabetic macula edema (DME)/non-proliferative diabetic retinopathy (NPDR)/ proliferative diabetic retinopathy (PDR), retinal vein occlusions related macular edema, and choroidal neovascular (CNV) secondary to multiple retinal diseases. * Undergo intravitreal anti-VEGF therapy

Exclusion criteria

* unable to receive OCT examination * Severe corneal opacity, cataract that affect OCT examination

Design outcomes

Primary

MeasureTime frameDescription
Visual acuity1 yearLogMAR visual acuity
Central subfield thickness1 yearhe central subfield is defined as the circular area 1 mm in diameter centered around the center point of the fovea

Countries

China

Contacts

Primary ContactWenbin Wei, MD
weiwenbintr@163.com010-58269523

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026