Conbercept

DRUG20 trials

Sponsors

Chengdu Kanghong Biotech Co., Ltd., Novartis Pharmaceuticals, Xiaodong Sun, Ruijin Hospital, The Eye Hospital of Wenzhou Medical University

Conditions

Age-related Macular DegenerationChoroidal Neovascular MembraneChoroidal NeovascularizationCircumscribed Choroidal HaemangiomaConberceptDiabete MellitusDiabetes Mellitus, Type 2Diabetic Macular Edema

Early Phase 1

Intravitreal Conbercept After Vitrectomy

CompletedNCT03426540

Tianjin Medical University Eye HospitalEarly Proliferative Diabetic Retinopathy

Start: 2017-01-01End: 2019-02-28Updated: 2019-04-30

Safety and Effectiveness of Intravitreal Conbercept for Exudative Circumscribed Choroidal Haemangioma

Sun Yat-sen UniversityCircumscribed Choroidal Haemangioma

Start: 2018-06-06End: 2019-06-06Target: 50Updated: 2018-06-27

Application of Intravitreal Conbercept Injection as a Primary Treatment for Exudative Circumscribed Choroidal Haemangioma

Sun Yat-sen UniversityCircumscribed Choroidal Haemangioma

Start: 2014-08-28End: 2020-01-01Target: 50Updated: 2019-06-04

Phase 2

Efficacy and Safety of Conbercept in Macular Edema Secondary to Retinal Vein Occlusion

Chengdu Kanghong Biotech Co., Ltd.Retinal Vein Occlusion

Start: 2012-05-31End: 2014-03-31Target: 60Updated: 2014-03-27

An Open, Single-center, Safety and Efficacy Study of Conbercept in Patients With Very Low Vision Secondary to Wet Age-related Macular Degeneration (wAMD)

Chengdu Kanghong Biotech Co., Ltd.Very Low Vision Secondary to Wet Age-related Macular Degeneration

Start: 2011-12-31Target: 30Updated: 2014-07-22

Intravitreal Conbercept for Idiopathic Choroidal Neovascularization

Jiao MingfeiIdiopathic Choroidal Neovascularization

Start: 2016-06-30Target: 50Updated: 2016-08-11

Conbercept in Choroidal Neovascularization Secondary to Uveitis

Chongqing Medical UniversityChoroidal Neovascularization, Uveitis

Start: 2016-11-30End: 2018-11-30Target: 40Updated: 2016-10-17

Evaluation of RC28-E Injection in Diabetic Macular Edema

CompletedNCT04782115

RemeGen Co., Ltd.Diabetic Macular Edema

Start: 2021-03-17End: 2023-07-31Updated: 2023-12-18

Phase 3

Safety and Efficacy Study of Conbercept in Diabetic Macular Edema (DME) (Sailing)

Chengdu Kanghong Biotech Co., Ltd.Diabetic Macular Edema

Start: 2014-07-31End: 2017-09-30Target: 248Updated: 2016-01-06

Phase 4

Head to Head Study of Anti-VEGF Treatment.

CompletedNCT02577107

Novartis PharmaceuticalsAge-related Macular Degeneration

Start: 2016-01-13End: 2016-07-09Updated: 2017-11-30

Efficacy and Safety of Treat-and-Extend Regimen Versus Pro Re Nata of Conbercept in Age-related Macular Degeneration

Xiaodong SunAge-related Macular Degeneration

Start: 2016-09-30End: 2020-09-30Updated: 2020-05-19

Conbercept Injection in Treatment of Severe Proliferative Diabetic Retinopathy

CompletedNCT02816710

Ruijin HospitalProliferative Diabetic Retinopathy, Tractional Retinal Detachment

Start: 2016-07-31End: 2017-09-30Updated: 2019-11-21

Initial Versus Delayed PDT Combination With Conbercept in PCV

CompletedNCT02821520

The Eye Hospital of Wenzhou Medical UniversityPolypoidal Choroidal Vasculopathy

Start: 2017-01-31End: 2019-06-30Target: 80Updated: 2019-07-19

The Efficacy Assessment of Intravitreal Injection of Conbercept in Patients With Polypoidal Choroidal Vasculopathy (PCV)

Chengdu Kanghong Biotech Co., Ltd.Polypoidal Choroidal Vasculopathy (PCV)

Start: 2015-10-31End: 2018-12-31Target: 300Updated: 2017-07-19

Efficacy and Safety of Conbercept for Diabetic Macular Edema Combined With Severe Non-proliferative Diabetic Retinopathy

Active, not recruitingNCT06305143

Shanghai Eye Disease Prevention and Treatment CenterDiabetic Macular Edema

Start: 2024-04-01End: 2025-07-01Target: 58Updated: 2025-05-30

Unknown Phase

PRP vs PRP+IVC for Severe nPDR

Ruijin HospitalDiabete Mellitus, Diabetic Retinopathy, Severe Nonproliferative Diabetic Retinopathy

Start: 2019-01-18End: 2021-09-30Target: 40Updated: 2019-03-05

Effects of Adding Triamcinolone Acetonide to Conbercept Treatment for Refractory Diabetic Macular Edema (CONTE)

Zhongshan Ophthalmic Center, Sun Yat-sen UniversityDiabetes Mellitus, Type 2, Macular Edema

Start: 2020-11-12End: 2021-12-31Target: 50Updated: 2020-11-17

Anti-VEGF in Real-world

Wenbin WeiChoroidal Neovascular Membrane, Diabetic Macular Edema, Neovascular Age-related Macular Edema +3

Start: 2022-01-01End: 2023-05-01Target: 1000Updated: 2022-02-03

Conbercept for Polypoidal Choroidal Vasculopathy（START Study）

CompletedNCT05229237

Peking Union Medical College HospitalConbercept, Polypoidal Choroidal Vasculopathy

Start: 2018-05-01End: 2021-12-05Updated: 2022-02-08

Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy

RecruitingNCT06717412

Wang YushengRetinopathy of Prematurity (ROP)

Start: 2024-11-29End: 2028-01-31Target: 146Updated: 2026-07-30

Related Papers

Simultaneous inhibition of fibroblast growth factor-2 and vascular endothelial growth factor-a with RC28-E in diabetic macular edema: a phase 2 randomised trial

British Journal of Ophthalmology2025-03-231 citations

A Randomized, Controlled Trial of Treat-and-Extend vs. Pro Re Nata Regimen for Neovascular Age-Related Macular Degeneration

Frontiers in Medicine2022-06-2011 citations

Efficacy of Initial vs. Delayed Photodynamic Therapy in Combination With Conbercept for Polypoidal Choroidal Vasculopathy

Frontiers in Medicine2022-02-091 citations

Intravitreal conbercept for diabetic macular oedema: 2-year results from a randomised controlled trial and open-label extension study

British Journal of Ophthalmology2021-05-1747 citations