Development of LIFU for Clinical Purposes
Conditions
Keywords
low-intensity focused ultrasound, transcranial magnetic stimulation
Brief summary
This project examines the effects of various durations of noninvasive neuromodulation on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, a functional Magnetic Resonance Image (fMRI) and computed tomography (CT). These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions of the hand.
Interventions
LIFU application using various durations, responses of neuromodulation recorded using TMS and EMG.
Sponsors
Virginia Polytechnic Institute and State University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Multi-visit study, testing various LIFU durations
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Above criteria and must understand and speak English.
Exclusion criteria
* Contraindications to MRI, CT, or TMS 1. Claustrophobia 2. Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 3. Pregnancy 4. Active medical disorder or treatment with potential CNS effects 5. History of neurologic disorder 6. History of head injury resulting in loss of consciousness for \>10 minutes 7. History of alcohol or drug dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Waveforms | Outcomes assessed throughout participation - an average of 3 weeks. | Changes in waveform peak will be observed per each variable application of LIFU |
Countries
United States
Outcome results
None listed