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Low-intensity focused ultrasound

DEVICE15 trials

Sponsors

Seoul National University Hospital, Virginia Polytechnic Institute and State University, Laureate Institute for Brain Research, Inc., University of Virginia, NaviFUS Corporation

Conditions

Alcohol Use DisorderAnxietyAnxiety DisorderBrain TumorBrain Tumor, RecurrentChronic PainCocaine AbuseCocaine Dependence

Phase 1

Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma
RecruitingNCT07343986
University of VirginiaGlioblastoma (GBM)
Start: 2026-01-01End: 2028-12-01Target: 12Updated: 2026-01-21

Phase 3

A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
RecruitingNCT06496971
NaviFUS CorporationBrain Tumor, Brain Tumor, Recurrent, Glioblastoma +5
Start: 2024-11-08End: 2027-03-31Target: 32Updated: 2024-11-14

Unknown Phase

Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury
CompletedNCT04306601
Seoul National University HospitalTraumatic Brain Injury With Prolonged Loss of Consciousness
Start: 2020-06-25End: 2022-12-22Updated: 2024-04-17
Investigation of Low-intensity Focused Ultrasound Parameters
CompletedNCT05134233
Virginia Polytechnic Institute and State UniversityDevelopment of LIFU for Clinical Purposes
Start: 2022-01-14End: 2024-03-11Updated: 2025-01-23
Investigation of the Duration of Low-intensity Focused Ultrasound
Enrolling by invitationNCT05147103
Virginia Polytechnic Institute and State UniversityDevelopment of LIFU for Clinical Purposes
Start: 2022-08-26End: 2026-06-30Target: 80Updated: 2025-07-04
Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression
CompletedNCT05697172
Laureate Institute for Brain Research, Inc.Major Depressive Disorder
Start: 2022-12-15End: 2024-02-06Updated: 2024-08-05
LIFU for Anxiety Management
Active, not recruitingNCT05839847
Virginia Polytechnic Institute and State UniversityAnxiety
Start: 2023-12-20End: 2026-04-01Updated: 2025-04-04
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
NCT05857852
University of VirginiaCocaine Abuse, Cocaine Dependence, Cocaine Use Disorder +1
Start: 2023-03-01End: 2025-03-01Target: 30Updated: 2023-05-15
Decision Making in Chronic Pain and Alcohol Use Disorder
SuspendedNCT05901610
Virginia Polytechnic Institute and State UniversityAlcohol Use Disorder, Chronic Pain
Start: 2024-06-28End: 2026-06-30Target: 10Updated: 2026-02-03
Low-Intensity Focused Ultrasound and the Complex Patient
RecruitingNCT06297200
Virginia Polytechnic Institute and State UniversityAnxiety Disorder, Chronic Pain, Opioid Use Disorder
Start: 2024-12-04End: 2026-10-31Target: 25Updated: 2025-11-03
Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke
Not yet recruitingNCT06875206
Duke UniversityHemianopia, Occipital Lobe Infarct, Quadrantanopia +4
Start: 2026-03-01End: 2027-04-01Target: 28Updated: 2026-02-20
Dose-Dependent Effects of Low-Intensity Focused Ultrasound
RecruitingNCT07099950
Laureate Institute for Brain Research, Inc.Healthy Controls
Start: 2025-04-22End: 2026-12-31Target: 66Updated: 2025-10-16
Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
RecruitingNCT07166289
Laureate Institute for Brain Research, Inc.Treatment-Resistant Depression
Start: 2025-09-30End: 2030-07-01Target: 140Updated: 2026-03-02
Promoting Recovery After Brain Injury Using Focused Ultrasound
RecruitingNCT07277309
Massachusetts General HospitalConsciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Start: 2026-03-01End: 2029-07-01Target: 36Updated: 2026-02-18
Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy
Enrolling by invitationNCT07353918
Carilion ClinicEpilepsy Comorbidities, Epilepsy (Treatment Refractory)
Start: 2025-10-13End: 2028-05-01Target: 6Updated: 2026-01-21

Related Papers

Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.
2025-09-25