Healthy
Conditions
Brief summary
A comparison of the glycaemic response and insulinaemic response to glucose, Nutralys S85 Plus pea protein and whey protein using a single-blind, randomised, repeat measure, crossover design trial.
Detailed description
A single-blind, randomised, repeat measure, crossover design trial will be used to study the glycaemic response and insulinaemic response following consumption of five products: one reference product (50 g available carbohydrate Glucose) and four test products (50 g available carbohydrate Glucose with 10 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 20 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 10 g Whey protein concentrate and 50 g available carbohydrate Glucose with 20 g Whey protein concentrate).
Interventions
DIETARY_SUPPLEMENT10 g NUTRALYS®S85 Plus pea protein
To determine the glycaemic response and insulinaemic response to 50g Glucose + 10 g NUTRALYS®S85 Plus pea protein.
DIETARY_SUPPLEMENT20 g NUTRALYS®S85 Plus pea protein
To determine the glycaemic response and insulinaemic response to 50g Glucose + 20 g NUTRALYS®S85 Plus pea protein.
DIETARY_SUPPLEMENT10 g Whey protein concentrate
To determine the glycaemic response and insulinaemic response to 50g Glucose + 10 g Whey protein concentrate.
DIETARY_SUPPLEMENT20 g Whey protein concentrate
To determine the glycaemic response and insulinaemic response to 50g Glucose + 20 g Whey protein concentrate.
DIETARY_SUPPLEMENT50 g Glucose
To determine the glycaemic response and insulinaemic response to 50g Glucose
Sponsors
Roquette Freres
Oxford Brookes University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
single-blind
Intervention model description
single-blind, randomised, repeat measure, crossover design trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 18 to 60 years * Body mass index (BMI) less than 30kg/m2
Exclusion criteria
* Pregnant or lactating * Fasting blood glucose value \> 6.1 mmol/l * Any known food allergy or intolerance * Medical condition(s) or medication(s) known to affect glucose regulation or appetite and/or which influence digestion and absorption of nutrients * Known history of diabetes mellitus or the use of antihyperglycaemic drugs or insulin to treat diabetes and related conditions * Major medical or surgical event requiring hospitalization within the preceding 3 months * Use of steroids, protease inhibitors or antipsychotics (all of which have major effects on glucose metabolism and body fat distribution) * Unable to comply with experimental procedures or did not follow GR testing safety guidelines.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood glucose response from baseline for 3 hours | 3 hours | Change in postprandial blood glucose response from baseline was measured at 15 min, 30 min, 45 min, 1 hour, 1.5 hours, 2 hours, 2.5 hours and 3 hours |
| Change in plasma insulin response from baseline for 3 hours | 3 hours | Change in postprandial plasma insulin response from baseline was measured at 15 min, 30 min, 45 min, 1 hour, 1.5 hours, 2 hours, 2.5 hours and 3 hours |
| Area under the blood glucose concentration versus time curve | 3 hours | Area under the blood glucose concentration versus time curve was calculated by trapezoidal rule |
| Area under the plasma insulin concentration versus time curve | 3 hours | Area under the plasma insulin concentration versus time curve was calculated by trapezoidal rule |
| Peak blood glucose concentration (Cmax) | 0-3 hours | Peak blood glucose concentration (Cmax) after consumption of the test food |
| Peak plasma insulin concentration (Cmax) | 0-3 hours | Peak plasma insulin concentration (Cmax) after consumption of the test food |
| Time of blood glucose peak (Tmax) | 0-3 hours | Time of blood glucose peak after consumption of the test food |
| Time of plasma insulin peak (Tmax) | 0-3 hours | Time of plasma insulin peak after consumption of the test food |
Countries
United Kingdom
Outcome results
None listed