Thyrotoxicosis
Conditions
Brief summary
Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.
Detailed description
Background: Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis. Methods: The files of 27 patients who underwent preoperative TPE for thyrotoxicosis between January 1999 and February 2019 were retrospectively analyzed. The demographic and clinical features of the patients were included.
Interventions
Therapeutic plasma exchange filtrates plasma and decreases thyroid hormone concentration in the blood
Sponsors
Baskent University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* thyrotoxicosis unresponsive to medication * adverse reaction to the medications * need for rapid treatment in patients that need urgent surgery
Exclusion criteria
* The patients who did not undergo surgery post-therapeutic plasma exchange * Preoperative hypocalcemia, * hemodynamically unstable patients * patients not suitable for central catheter placement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thyroid hormone levels of patients after therapeutic plasma exchange | 1 week before the operation | Concentration of serum thyroid hormone levels before thyroidectomy |
Outcome results
None listed