Healthy Volunteers
Conditions
Keywords
Energy expenditure, metabolism, inosine
Brief summary
Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by athletes. For this purpose, investigators will measure the basal metabolic rate by indirect calorimetry. Study participants will then take inosine dissolved in water or placebo and energy expenditure will be assessed again.
Interventions
DIETARY_SUPPLEMENTInosine
2 grams of inosine dissolved in 250 ml water taken by mouth
OTHERPlacebo
250 ml water taken by mouth
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male volunteers * BMI between 18-27 kg/m2 * Age between 18 and 40 years
Exclusion criteria
* Chronic concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus), * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons, * Thyroid disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| resting energy expenditure after Inosine | one hour after oral intake of inosine | resting energy expenditure (REE) assessed by indirect calorimetry after oral intake of two grams of inosine as compared to placebo |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in energy expenditure | one hour after oral intake of inosine | \- Difference in EE between baseline measurement and measurement one hour after administration of inosine or control, respectively, at each study visit. |
| Change in Respiratory Quotient | one hour after oral intake of inosine | \- Respiratory quotient (RQ) as an indicator of substrate oxidation one hour after oral intake of two grams of inosine |
| Serum inosine level | 0 hours, 1 hour, 2 hours | Serum inosine levels after ingestion of inosine |
Countries
Switzerland
Outcome results
None listed